Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer

被引：43

作者：

Rhodes, Lyndsay V. ^{[1
]}

Tilghman, Syreeta L. ^{[4
]}

Boue, Stephen M. ^{[3
]}

Wang, Shuchun ^{[1
]}

Khalili, Hafez ^{[1
]}

Muir, Shannon E. ^{[1
]}

Bratton, Melyssa R. ^{[2
]}

Zhang, Qiang ^{[5
]}

Wang, Guangdi ^{[5
,6
]}

Burow, Matthew E. ^{[1
,2
]}

Collins-Burow, Bridgette M. ^{[1
]}

机构：

[1] Tulane Univ, Hlth Sci Ctr, Sect Hematol & Med Oncol, Dept Med, New Orleans, LA 70112 USA

[2] Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA

[3] Xavier Univ Louisiana, USDA, New Orleans, LA 70125 USA

[4] Xavier Univ Louisiana, Coll Pharm, New Orleans, LA 70125 USA

[5] Xavier Univ Louisiana, RCMI Canc Res Ctr, New Orleans, LA 70125 USA

[6] Xavier Univ Louisiana, Dept Chem, New Orleans, LA 70125 USA

来源：

ONCOLOGY LETTERS | 2012年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

triple-negative breast cancer; microRNA; tumorigenesis; glyceollins; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR GENE; ANTIESTROGENIC ACTIVITIES; MICRORNA-21; TARGETS; IN-VITRO; EXPRESSION; SOY; MODELS; MIR-21; PHYTOCHEMICALS;

D O I：

10.3892/ol.2011.460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to investigate the effects of glyceollins on the suppression of tumorigenesis in triple-negative breast carcinoma cell lines. We further explored the effects of glyceollins on microRNA and protein expression in MDA-MB-231 cells. Triple-negative (ER-, PgR- and Her2/neu-) breast carcinoma cells were used to test the effects of glyceollins on tumorigenesis in vivo. Following this procedure, unbiased microarray analysis of microRNA expression was performed. Additionally, we examined the changes in the proteome induced by glyceollins in the MDA-MB-231 cells. Tumorigenesis studies revealed a modest suppression of MDA-MB-23I and MDA-MB-468 cell tumor growth in vivo. In response to glyceollins we observed a distinct change in microRNA expression profiles and proteomes of the triple-negative breast carcinoma cell line, MDA-MB-231. Our results demonstrated that the glyceollins, previously described as anti-estrogenic agents, also exert antitumor activity in triple-negative breast carcinoma cell systems. This activity correlates with the glyceollin alteration of microRNA and proteomic expression profiles.

引用

页码：163 / 171

页数：9

共 81 条

[61] Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma [J].

Qi, Liqiang ;

Bart, Joost ;

Tan, Lu Ping ;

Platteel, Inge ;

van der Sluis, Tineke ;

Huitema, Sippie ;

Harms, Geert ;

Fu, Li ;

Hollema, Harry ;

van den Berg, Anke .

BMC CANCER, 2009, 9

[62] MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer [J].

Radojicic, Jelena ;

Zaravinos, Apostolos ;

Vrekoussis, Thomas ;

Kafousi, Maria ;

Spandidos, Demetrios A. ;

Stathopoulos, Efstathios N. .

CELL CYCLE, 2011, 10 (03) :507-517

[63] The impact of expression profiling on prognostic and predictive testing in breast cancer [J].

Reis, JS ;

Westbury, C ;

Pierga, JY .

JOURNAL OF CLINICAL PATHOLOGY, 2006, 59 (03) :225-231

[64] Triple negative tumours: a critical review [J].

Reis-Filho, J. S. ;

Tutt, A. N. J. .

HISTOPATHOLOGY, 2008, 52 (01) :108-118

[65] Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence [J].

Rhodes, Lyndsay V. ;

Muir, Shannon E. ;

Elliott, Steven ;

Guillot, Lori M. ;

Antoon, James W. ;

Penfornis, Patrice ;

Tilghman, Syreeta L. ;

Salvo, Virgilio A. ;

Fonseca, Juan P. ;

Lacey, Michelle R. ;

Beckman, Barbara S. ;

McLachlan, John A. ;

Rowan, Brian G. ;

Pochampally, Radhika ;

Burow, Matthew E. .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 121 (02) :293-300

[66] Relationship of nm23 to proteolytic factors, proliferation and motility in breast cancer tissues and cell lines [J].

Russell, RL ;

Pedersen, AN ;

Kantor, J ;

Geisinger, K ;

Long, R ;

Zbieranski, N ;

Townsend, A ;

Shelton, B ;

Brünner, N ;

Kute, TE .

BRITISH JOURNAL OF CANCER, 1998, 78 (06) :710-717

[67] Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis [J].

Salvo, Virgilo A. ;

Boue, Stephen M. ;

Fonseca, Juan P. ;

Elliott, Steven ;

Corbitt, Cynthia ;

Collins-Burow, Bridgette M. ;

Curiel, Tyler J. ;

Srivastav, Sudesh K. ;

Shih, Betty Y. ;

Carter-Wientjes, Carol ;

Wood, Charles E. ;

Erhardt, Paul W. ;

Beckman, Barbara S. ;

McLachlan, John A. ;

Cleveland, Thomas E. ;

Burow, Matthew E. .

CLINICAL CANCER RESEARCH, 2006, 12 (23) :7159-7164

[68] Down-Regulation of Cyclin E1 Expression by MicroRNA-195 Accounts for Interferon-β-Induced Inhibition of Hepatic Stellate Cell Proliferation [J].

Sekiya, Yumiko ;

Ogawa, Tomohiro ;

Iizuka, Masashi ;

Yoshizato, Katsutoshi ;

Ikeda, Kazuo ;

Kawada, Norifumi .

JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (10) :2535-2542

[69] MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression [J].

Song, Bao ;

Wang, Chuanxi ;

Liu, Jie ;

Wang, Xingwu ;

Lv, Liyan ;

Wei, Ling ;

Xie, Li ;

Zheng, Yan ;

Song, Xianrang .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2010, 29

[70] Clinical review 97 - Potential health benefits of dietary phytoestrogens: A review of the clinical, epidemiological, and mechanistic evidence [J].

Tham, DM ;

Gardner, CD ;

Haskell, WL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (07) :2223-2235

← 1 2 3 4 5 6 7 8 9 →