Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

被引：11

作者：

Lin, Ling ^{[1
,2
]}

Ni, SiYang ^{[1
]}

Wu, LinZhuan ^{[1
]}

Wang, YiGuang ^{[1
]}

Wang, YuCheng ^{[1
]}

Tao, PeiZhen ^{[1
]}

He, WeiQing ^{[1
]}

Wang, XiangJing ^{[2
]}

机构：

[1] CAMS & PUMC, Key Lab Biotechnol Antibiot, Minist Hlth, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] NE Agr Univ, Harbin 150030, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 10期

基金：

中国国家自然科学基金;

关键词：

biosynthesis; gdmP; geldanamycin; 4,5-dihydro-thiazinogeldanamycin; ANTITUMOR AGENT; GELDANAMYCIN; BIOSYNTHESIS; ANTIBIOTICS; POLYKETIDE;

D O I：

10.1271/bbb.110361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel geldanamycin derivative, 4,5-dihydro-thiazino-geldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.

引用

页码：2042 / 2045

页数：4

共 13 条

[11] Novel Polyketide Metabolites from Streptomyces rimosus Mutant Strain R1059
Myrna A Deseo
Iain S Hunter
Peter G Waterman
The Journal of Antibiotics, 2005, 58 : 822 - 827
[12] Studies of precursor-directed biosynthesis with streptomyces, part 4.: Novel α-L-rhamnopyranosides from a single strain of Streptomyces by supplement-induced biosynthetic steps
Grond, S
Papastavrou, I
Zeeck, A
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2002, 2002 (19) : 3237 - 3242
[13] Novel 3-(1-acetyl-5-(substituted-phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-7-fluoro-2H-chromen-2-one Derivatives: Synthesis and Anticancer Activity
Cai, Zheng-Yu
Yang, Yang
Liu, Xin-Hua
Qi, Xing-Bao
LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (09) : 640 - 643

← 1 2 →