Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

被引：11

作者：

Lin, Ling ^{[1
,2
]}

Ni, SiYang ^{[1
]}

Wu, LinZhuan ^{[1
]}

Wang, YiGuang ^{[1
]}

Wang, YuCheng ^{[1
]}

Tao, PeiZhen ^{[1
]}

He, WeiQing ^{[1
]}

Wang, XiangJing ^{[2
]}

机构：

[1] CAMS & PUMC, Key Lab Biotechnol Antibiot, Minist Hlth, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] NE Agr Univ, Harbin 150030, Peoples R China

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 10期

基金：

中国国家自然科学基金;

关键词：

biosynthesis; gdmP; geldanamycin; 4,5-dihydro-thiazinogeldanamycin; ANTITUMOR AGENT; GELDANAMYCIN; BIOSYNTHESIS; ANTIBIOTICS; POLYKETIDE;

D O I：

10.1271/bbb.110361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel geldanamycin derivative, 4,5-dihydro-thiazino-geldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.

引用

页码：2042 / 2045

页数：4

共 13 条

[1] Thiazinogeldanamycin, a New Geldanamycin Derivative Produced by Streptomyces hygroscopicus 17997
Ni Siyang
Wu, Linzhuan
Wang, Hongyuan
Gan, Maoluo
Wang, Yucheng
He, Weiqing
Wang, Yiguang
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 21 (06) : 599 - 603
[2] 7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997
Ni, Siyang
Wu, Linzhuan
Wang, Hongyuan
Wang, Yiguang
He, Weiqing
Li, Yonghai
Jia, Changhong
Li, Shufen
Wang, Yucheng
JOURNAL OF ANTIBIOTICS, 2010, 63 (10): : 623 - 625
[3] A pair of sulfur-containing geldanamycin analogs, 19-S-methylgeldanamycin and 4,5-dihydro-19-S-methylgeldanamycin, from Streptomyces hygroscopicus 17997
Liu, Xin
Li, Jingyan
Ni, Siyang
Wu, Linzhuan
Wang, Hongyuan
Lin, Ling
He, Weiqing
Wang, Yiguang
JOURNAL OF ANTIBIOTICS, 2011, 64 (07): : 519 - 522
[4] A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997
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He, Weiqing
Wang, Yucheng
Wang, Yiguang
Shao, Rongguang
JOURNAL OF ANTIBIOTICS, 2008, 61 (06): : 347 - 355
[5] A New Post-PKS Modification Process in the Carbamoyltransferase Gene Inactivation Strain of Streptomyces hygroscopicus 17997
Yonghai Li
Weiqing He
Yucheng Wang
Yiguang Wang
Rongguang Shao
The Journal of Antibiotics, 2008, 61 : 347 - 355
[6] Enhanced rapamycin production through kinetic and purification studies by mutant strain of Streptomyces hygroscopicus NTG-30-27
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[7] 19-[(1′S,4′R)-4′-Hydroxy-1′-methoxy-2′-oxopentyl]geldanamycin, a Natural Geldanamycin Analogue from Streptomyces hygroscopicus 17997
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