Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains

被引：21

作者：

Freitas, Priscilla Ramos ^{[1
]}

Justino de Araujo, Ana Carolina ^{[1
]}

dos Santos Barbosa, Cristina Rodrigues ^{[2
]}

Muniz, Debora Feitosa ^{[1
]}

Rocha, Janaina Esmeraldo ^{[1
]}

de Araujo Neto, Jose Bezerra ^{[1
]}

Costa da Silva, Maria Milene ^{[1
]}

Silva Pereira, Raimundo Luiz ^{[3
]}

da Silva, Luiz Everson ^{[4
]}

do Amaral, Wanderlei ^{[4
]}

Deschamps, Cicero ^{[4
]}

Tintino, Saulo Relison ^{[1
]}

Ribeiro-Filho, Jaime ^{[5
]}

Melo Coutinho, Henrique Douglas ^{[1
]}

机构：

[1] Reg Univ Cariri, Lab Microbiol & Mol Biol, LMBM, Crato, Ceara, Brazil

[2] Reg Univ Cariri, Lab Bioprospecting Semiarid & Alternat Methods, LABSEMA, Crato, Ceara, Brazil

[3] Reg Univ Cariri, Lab Simulat & Mol Spect, LASEMOL, Crato, Ceara, Brazil

[4] Univ Fed Parana, Curitiba, Parana, Brazil

[5] Oswaldo Cruz Fdn IGM FIOCRUZ BA, Goncalo Moniz Inst, Rua Waldemar Falcao 121, BR-40296710 Salvador, BA, Brazil

来源：

MICROBIAL PATHOGENESIS | 2020年 / 145卷

关键词：

Baccharis coridifolia; Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; Antibacterial agents; Essential oils; DRACUNCULIFOLIA DC; ASTERACEAE; L; ANTIBIOTICS; ASTEREAE;

D O I：

10.1016/j.micpath.2020.104223

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Essential oils are secondary metabolites with immense pharmacological potential. These substances are abundantly produced by plants of the family Asteraceae, such as Baccharis coridifolia. Previous studies have demonstrated that this species has pharmacological properties that make it a promising source of new antibacterial agents. Therefore, the present study aimed to evaluate the antibacterial and antibiotic-modulating activity of Baccharis coridifolia essential oil against multidrug-resistant (MDR) strains. The phytochemical analysis was carried out by gas chromatography coupled to Mass Spectroscopy (GC/MS), and realized the Minimum Inhibitory Concentation (MIC) and antibiotic-modulation from the microdilution method in 96-well plates. It was revealed the presence of germacrene D (23.7%), bicyclogermacrene (17.1%), and (E)-caryophyllene (8.4%) as major components. The minimum inhibitory concentration of essential oil against strains of Pseudomonas aeruginosa (512 mu g/mL) and Staphylococcus aureus (128 mu g/mL) demonstrated clinically relevant antibacterial activity. In addition, the combination of subinhibitory doses of the oil with conventional antibiotics showed synergism, indicating potentiation of the antibacterial effect. In conclusion, the essential oil of Baccharis coridifolia (EOBc) presented antibacterial and antibiotic-modulating activities that place this species as a source of molecules useful in the fight against bacterial resistance.

引用

页数：5

共 32 条

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