A biodegradable functional water-responsive shape memory polymer for biomedical applications

被引：82
作者：
Guo, Yifan [1 ]
Lv, Ziying [1 ]
Huo, Yiru [1 ]
Sun, Lijie [1 ]
Chen, Shuo [1 ]
Liu, Zenghe [1 ]
He, Chuanglong [2 ]
Bi, Xiaoping [3 ]
Fan, Xianqun [3 ]
You, Zhengwei [1 ]
机构：
[1] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Int Joint Lab Adv Fiber & Low Dimens Mat, 2999 North Renmin Rd, Shanghai 201620, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Rd, Shanghai 201620, Peoples R China
[3] Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Key Lab Orbital Dis & Ocular Oncol, Dept Ophthalmol,Sch Med, 639 Zhizaoju Rd, Shanghai 200025, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 01期
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
FREE HYDROXYL-GROUPS; POLYESTER; COMPOSITES; RECOVERY;
D O I：
10.1039/c8tb02462f
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Shape memory polymers (SMPs) have exhibited great potential in biomedical applications. However, the typical triggers of shape recovery such as heat, UV light, and electricity may be harmful to humans. Accordingly, water-responsive SMPs have become significant, especially for in vivo applications, due to the intrinsic biocompatibility and ready availability of water. However, the reported water-responsive SMPs are limited and relatively complicated. Here, we design a new water-responsive SMP, poly(butanetetrol fumarate) (PBF); the properties of PBF could be modulated by curing. The cured PBF scaffolds exhibited high shape recovery and fixity rates (>95%). PBF showed good biodegradability, and it could support the attachment, viability and alkaline phosphatase activity of osteoblasts. Furthermore, PBF could be readily functionalized via pendant hydroxyl groups, which was demonstrated by the immobilization and controlled release of bone morphogenetic protein 2. We expect that PBF will be useful for various biomedical applications including water-responsive scaffolds, sensors or actuators.
引用
收藏
页码：123 / 132
页数：10
相关论文
共 24 条
[1]   Thermal and water dual-responsive shape memory poly(vinyl alcohol)/Al2O3 nanocomposite [J].
Bai, Quanming ;
Zhang, Gongzheng ;
Xu, Bo ;
Feng, Xianqi ;
Jiang, Haoyang ;
Li, Huanjun .
RSC ADVANCES, 2015, 5 (111) :91213-91217
[2]   A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix [J].
Bi, Xiaoping ;
You, Zhengwei ;
Gao, Jin ;
Fan, Xianqun ;
Wang, Yadong .
ACTA BIOMATERIALIA, 2014, 10 (06) :2814-2823
[3]   Design of a Smart Nerve Conduit Based on a Shape-Memory Polymer [J].
Chen, Cheng ;
Hu, Jinlian ;
Huang, Huahua ;
Zhu, Yong ;
Qin, Tingwu .
ADVANCED MATERIALS TECHNOLOGIES, 2016, 1 (04)
[4]   Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties [J].
Correia, Cristina O. ;
Leite, Alvaro J. ;
Mano, Joao F. .
CARBOHYDRATE POLYMERS, 2015, 123 :39-45
[5]  
Cui YL, 2014, J MATER CHEM B, V2, P5478
[6]   In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites [J].
Filion, Tera M. ;
Xu, Jianwen ;
Prasad, Manju L. ;
Song, Jie .
BIOMATERIALS, 2011, 32 (04) :985-991
[7]   Remote Controlled Multishape Polymer Nanocomposites with Selective Radiofrequency Actuations [J].
He, Zhengwang ;
Satarkar, Nitin ;
Xie, Tao ;
Cheng, Yang-Tse ;
Hilt, J. Zach .
ADVANCED MATERIALS, 2011, 23 (28) :3192-+
[8]   Phosphorylated poly(sebacoyl diglyceride) - a phosphate functionalized biodegradable polymer for bone tissue engineering [J].
Huang, Peng ;
Bi, Xiaoping ;
Gao, Jin ;
Sun, Lijie ;
Wang, Shaofei ;
Chen, Shuo ;
Fan, Xianqun ;
You, Zhengwei ;
Wang, Yadong .
JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (12) :2090-2101
[9]   Biodegradable, elastic shape-memory polymers for potential biomedical applications [J].
Lendlein, A ;
Langer, R .
SCIENCE, 2002, 296 (5573) :1673-1676
[10]   Light-induced shape-memory polymers [J].
Lendlein, A ;
Jiang, HY ;
Jünger, O ;
Langer, R .
NATURE, 2005, 434 (7035) :879-882
123