Epidemiology of low-grade serous ovarian cancer

被引：95
作者：
Plaxe, Steven C. [1 ]
机构：
[1] Rebecca & John Moores Univ Calif, Ctr Canc, Dept Reprod Med, Div Gynecol Oncol, San Diego, CA USA
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 198卷 / 04期
关键词：
descriptive epidemiology; ovarian cancer; Surveillance; Epidemiology; and End Results program; tumor grade;
D O I：
10.1016/j.ajog.2008.01.035
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: The objective of the study was to determine whether the epidemiology of low-grade ovarian serous cancers is distinct from that of high-grade ovarian serous cancers. STUDY DESIGN: The National Cancer Institute's Surveillance Epidemiology and End Results ( SEER) program reports incidence, and survival, data from representative population based cancer registries. The SEER data are analyzed to compare the descriptive epidemiologies of low-and high-grade lesions. RESULTS: Mean survival ( 99 vs 57 months) and age (55.5 vs 62.6 years) trends in annual incidence rate (-3.8% vs 1.4%), rate ratio of advanced to early disease (1.9 vs 10.2), rate ratio of post-to premenopausal incidence (5.0 vs 13.0). and difference in average age between advanced and early stage (none vs 2.5 years) are significantly different for patients with low-grade, compared with high-grade, disease. CONCLUSION: Epidemiology of low-grade tumors appears sufficiently different from that of high-grade lesions to support the concept that low-grade ovarian serous cancers constitute a distinct clinical, and perhaps biologic, entity.
引用
收藏
页码：459.e1 / 459.e9
页数：8
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