Intra- and Intercellular Quality Control Mechanisms of Mitochondria

被引：65

作者：

Kiriyama, Yoshimitsu ^{[1
]}

Nochi, Hiromi ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Kagawa Sch Pharmaceut Sci, Shido 1314-1, Sanuki, Kagawa 7692193, Japan

来源：

CELLS | 2018年 / 7卷 / 01期

关键词：

mitochondria; mitophagy; transmitophgy; PGC1; mitofusin; DRP1; MIRO1; CD38; NUCLEAR RESPIRATORY FACTORS; TRANSCRIPTION FACTOR; STRUCTURALLY DISTINCT; PGC-1; FAMILY; MITOPHAGY; FISSION; AUTOPHAGY; CELLS; UBIQUITIN; PINK1;

D O I：

10.3390/cells7010001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.

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页数：11

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