Lethal effect of dehydroleucodine (DhL) on amphibian Bufo arenarum embryos

被引：4

作者：

Elizabeth Moreno, Liliana ^{[1
,2
]}

Osvaldo Juarez, Americo ^{[1
]}

Eugenia Pelzer, Lilian ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, PROICO Area Farmacol 8504, RA-5700 San Luis, Argentina

[2] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Area Zool, RA-5700 San Luis, Argentina

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2012年 / 50卷 / 3-4期

关键词：

Toxicity; Bufo arenarum; Embryos; Anuran; Dehydroleucodine; SESQUITERPENE LACTONES;

D O I：

10.1016/j.fct.2011.12.037

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser which is used in popular medicine. Toxicity tests using embryos of amphibian have been widely used in order to predict toxic effects of different compounds. However, to our knowledge, there are not studies focussed on the toxic effects of dehydroleucodine on Bufo arenarum, which is an anuran widely distributed in South America. The effect of dehydroleucodine on the survival of embryos was evaluated in an acute test during the early life stage of B. arenarum embryos. Lethality and the degree of adverse effects were dehydroleucodine dose-dependent. Overall, amphibian early life stages appeared to be more susceptible to the embryotoxicity associated with exposure to dehydroleucodine, especially at concentration greater that 3 mM. This increased susceptibility may result from the relatively high rate of cellular differentiation and morphogenesis that occurs at this early stage of development. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：672 / 674

页数：3

共 14 条

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