Inflammation-based Prognostic Score in Patients with Living Donor Liver Transplantation for Hepatocellular Carcinoma

被引：30
作者：
Harimoto, Norifumi [1 ]
Yoshizumi, Tomoharu [1 ]
Shimagaki, Tomonari [1 ]
Nagatsu, Akihisa [1 ]
Motomura, Takashi [1 ]
Harada, Noboru [1 ]
Okabe, Hirohisa [1 ]
Itoh, Shinji [1 ]
Ikegami, Toru [1 ]
Uchiyama, Hideaki [1 ]
Soejima, Yuji [1 ]
Maehara, Yoshihiko [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka, Japan
来源：
ANTICANCER RESEARCH | 2016年 / 36卷 / 10期
关键词：
LDLT; neutrophillymphocyte ratio; platelet/lymphocyte ratio; prognostic nutritional index; TO-LYMPHOCYTE RATIO; NUTRITIONAL INDEX PNI; TUMOR SIZE; SURGICAL RESECTION; MILAN CRITERIA; RECURRENCE; SURVIVAL; NEUTROPHIL; PREDICTS; IMPACT;
D O I：
10.21873/anticanres.11137
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. Patients and Methods: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared. Risk factors for HCC recurrence were identified by univariate and multivariate analyses. Results: Both NLR and PLR were significantly increased in patients with recurrence. Multivariate analysis showed that des-gamma-carboxy prothrombin (DCP) >= 300 mAU/ml, NLR >= 2.66, <3 months between last HCC treatment to LDLT were independent predictors of DFS. Conclusion: Preoperative NLR was an independent, inflammation-based prognostic marker of DFS and was predictive of recurrence following LDLT.
引用
收藏
页码：5537 / 5542
页数：6
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