Unravelling biological roles and mechanisms of GABABR on addiction and depression through mood and memory disorders

被引：3
作者：
Wang, Yong S. [1 ]
Qiu, Tian Y. [2 ,3 ]
Fu, Qiang [4 ]
Xiong, Si Q. [1 ]
Wang, Ze Z. [1 ]
Lu, Ming F. [2 ,3 ]
Yang, Jian H. [5 ]
Hu, Zhen Z. [2 ,3 ,6 ]
机构：
[1] Nanchang Univ, Queen Mary Inst, Sch Med, Nanchang, Jiangxi, Peoples R China
[2] Nanchang Univ, Coll Basic Med, Dept Pathophysiol, Nanchang, Jiangxi, Peoples R China
[3] Nanchang Univ, Coll Basic Med, Jiangxi Prov Key Lab Tumor Pathogens & Mol Pathol, Nanchang, Jiangxi, Peoples R China
[4] Nanchang Univ, Jiangxi Prov Peoples Hosp, Dept Respirat, Dept Two, Nanchang, Jiangxi, Peoples R China
[5] Nanchang Univ, Coll Basic Med, Dept Physiol, Nanchang, Jiangxi, Peoples R China
[6] Nanchang Univ, Coll Basic Med, Dept Pathophysiol, Nanchang 330006, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 155卷
基金：
中国国家自然科学基金;
关键词：
GABA(B)R; Addiction; Depression; Synapse; Ion channels; Trafficking; GAMMA-AMINOBUTYRIC-ACID; REGULATED TRANSCRIPT PEPTIDE; PROTEIN SIGNALING PROTEINS; LONG-TERM POTENTIATION; CA2+ CHANNEL; SURFACE EXPRESSION; CALCIUM-CHANNELS; BINDING PROTEIN; MESSENGER-RNA; RECEPTORS FUNCTION;
D O I：
10.1016/j.biopha.2022.113700
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The metabotropic gamma-aminobutyric acid type B receptor (GABA(B)R) remains a hotspot in the recent research area. Being an idiosyncratic G-protein coupled receptor family member, the GABA(B)R manifests adaptively tailored functionality under multifarious modulations by a constellation of agents, pointing to cross-talk between receptors and effectors that converge on the domains of mood and memory. This review systematically summarizes the latest achievements in signal transduction mechanisms of the GABA(B)R-effector-regulator complex and probes how the up-and down-regulation of membrane-delimited GABA(B)Rs are associated with manifold intrinsic and extrinsic agents in synaptic strength and plasticity. Neuropsychiatric conditions depression and addiction share the similar pathophysiology of synapse inadaptability underlying negative mood-related processes, memory formations, and impairments. In the attempt to emphasize all convergent discoveries, we hope the insights gained on the GABA(B)R system mechanisms of action are conducive to designing more therapeutic candidates so as to refine the prognosis rate of diseases and minimize side effects.
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页数：11
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