Genetic determination of osteoporosis: Lessons learned from a large genome-wide linkage study

被引:0
作者
Xiong, Dong-Hai [1 ,2 ,3 ,4 ]
Wang, Jin-Tang [5 ]
Wang, Wei [1 ,2 ,3 ,4 ]
Guo, Yan-Fang [3 ,4 ,6 ]
Xiao, Peng [3 ,4 ]
Shen, Hui [7 ]
Jiang, Hui [6 ]
Chen, Yuan [6 ]
Deng, Hongyi [7 ]
Drees, Betty [7 ]
Recker, Robert R. [3 ,4 ]
Deng, Hong-Wen [1 ,2 ,6 ,7 ]
机构
[1] Xi An Jiao Tong Univ, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China
[2] Xi An Jiao Tong Univ, Inst Mol Genet, Xian 710049, Peoples R China
[3] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68131 USA
[4] Creighton Univ, Dept Biomed Sci, Omaha, NE 68131 USA
[5] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Orthoped, Xian, Shaanxi, Peoples R China
[6] Hunan Normal Univ, Coll Life Sci, Lab Mol & Stat Genet, Changsha 410081, Hunan, Peoples R China
[7] Univ Missouri, Sch Med, Kansas City, MO 64108 USA
关键词
osteoporosis; bone mineral density; genomic imprinting; sex-specific linkage analysis; autosomal linkage scan;
D O I
暂无
中图分类号
Q98 [人类学];
学科分类号
030303 ;
摘要
Osteoporosis is a common disease with strong genetic control. We performed an autosomal linkage scan in a large pedigree-based sample of 4,498 subjects for a composite osteoporosis phenotype that combines osteoporotic fracture (OF) and low bone mineral density (BMD). All of the subjects were U.S. Caucasians recruited in the Omaha area of Nebraska. Sex-specific linkage analyses and autosomal imprinting analyses were also conducted. For conventional linkage analyses in the total sample, we identified suggestive linkage on chromosomes l4q32 (LOD = 2.61), 7p14 (LOD = 2.42), and 11q25 (LOD = 2.09). In female subjects a significant linkage signal was detected on chromosome 14q22 (LOD = 3.53) and another two peaks were detected on chromosomes 7p14 (LOD = 3.07) and 9p21 (LOD = 2.29). Suggestive evidence of imprinted loci was found with paternally derived alleles on chromosomes 1q42 (LOD = 2.12) and 9q34 (LOD = 1.88). Some evidence of linkage to maternally derived alleles was found on chromosome 7q22 (LOD = 1.67). Our study provides new clues to osteoporosis genetic research and for the first time suggests that genomic imprinting effects may play a role in the etiology of osteoporosis.
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页码:593 / 608
页数:16
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