Analysis of Composition, Molecular Weight, and Water Content Variations in Sodium Alginate Using Solid-State NMR Spectroscopy

被引：26

作者：

Sperger, Diana M. ^{[1
]}

Fu, Shao ^{[2
]}

Block, Lawrence H. ^{[2
]}

Munson, Eric J. ^{[1
,3
]}

机构：

[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA

[2] Duquesne Univ, Grad Sch Pharmaceut Sci, Pittsburgh, PA 15282 USA

[3] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 100卷 / 08期

基金：

美国国家科学基金会;

关键词：

solid-state NMR; excipients; polymers; alginate; structure; molecular weight; viscosity; relaxation time; hydration; mobility; URONIC ACID SEQUENCE; MATRIX TABLETS; C-13; NMR; RELEASE; GEL; RESOLUTION; SPECTRA; EROSION;

D O I：

10.1002/jps.22559

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solid-state nuclear magnetic resonance (SSNMR) spectroscopy has become more prevalent in the pharmaceutical industry due to its nondestructive nature and the wealth of information it can provide on a wide variety of solid samples. In this study, SSNMR spectra and relaxation times were used to analyze differences in monomer composition, molecular weight (MW), and water content among various sodium alginate samples. Differences in structure could be determined via spectral deconvolution of SSNMR spectra, and differences in intrinsic viscosity, MW, and water content were found to correlate to SSNMR relaxation times. The technique was found to be selective and sensitive enough to detect these changes in sodium alginate even when diluted with another excipient and compressed into a tablet. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3441-3452, 2011

引用

页码：3441 / 3452

页数：12

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