Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer

被引:20
作者
Jia, Yanpeng [1 ,2 ,3 ]
Song, Yang [5 ]
Qu, Ying [1 ,2 ,3 ]
Peng, Jinrong [1 ,2 ,3 ]
Shi, Kun [1 ,2 ,3 ]
Du, Dan [5 ]
Li, He [4 ]
Lin, Yuehe [5 ]
Qian, Zhiyong [1 ,2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China
[3] Collaborat Innovat Ctr, Chengdu 610041, Sichuan, Peoples R China
[4] Chengdu Univ Informat Technol, Coll Optoelect Technol, Chengdu 610225, Sichuan, Peoples R China
[5] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99163 USA
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
inorganic nanoparticles; photoacoustic imaging; porous structure; photothermal therapy; chemotherapy; NEAR-INFRARED LIGHT; GOLD NANOPARTICLES; DRUG-RELEASE; CELL-DEATH; APOPTOSIS; CHEMOTHERAPY; EFFICIENCY; NANOSHEETS; PALLADIUM; NANORODS;
D O I
10.1007/s12274-020-2800-2
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles' targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.
引用
收藏
页码:1739 / 1748
页数:10
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