Targeted drug delivery to tumors: Myths, reality and possibility

被引:1396
作者
Bae, You Han
Park, Kinam [1 ]
机构
[1] Univ Utah, Coll Pharm, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
关键词
CANCER STEM-CELLS; BLOCK-COPOLYMER MICELLES; IN-VITRO; VASCULAR-PERMEABILITY; PROTEIN; SIZE; NANOPARTICLES; TRANSPORT; NEOCARZINOSTATIN; HETEROGENEITY;
D O I
10.1016/j.jconrel.2011.06.001
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:198 / 205
页数:8
相关论文
共 91 条
  • [1] Is tumor growth sustained by rare cancer stem cells or dominant clones?
    Adams, Jerry M.
    Strasser, Andreas
    [J]. CANCER RESEARCH, 2008, 68 (11) : 4018 - 4021
  • [2] Drug targeting and tumor heterogeneity
    Bae, You Han
    [J]. JOURNAL OF CONTROLLED RELEASE, 2009, 133 (01) : 2 - 3
  • [3] HEPATIC CIRCULATION - POTENTIAL FOR THERAPEUTIC INTERVENTION
    BALLET, F
    [J]. PHARMACOLOGY & THERAPEUTICS, 1990, 47 (02) : 281 - 328
  • [4] Silica particles:: A novel drug-delivery system
    Barbé, C
    Bartlett, J
    Kong, LG
    Finnie, K
    Lin, HQ
    Larkin, M
    Calleja, S
    Bush, A
    Calleja, G
    [J]. ADVANCED MATERIALS, 2004, 16 (21) : 1959 - 1966
  • [5] Chemo-embolization of experimental liver metastases.: Part I:: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy
    Bastian, P
    Bartkowski, R
    Köhler, H
    Kissel, T
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1998, 46 (03) : 243 - 254
  • [6] Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments
    Beduneau, Arnaud
    Saulnier, Patrick
    Hindre, Francois
    Clavreul, Anne
    Leroux, Jean-Christophe
    Benoit, Jean-Pierre
    [J]. BIOMATERIALS, 2007, 28 (33) : 4978 - 4990
  • [7] Birner P, 2001, CLIN CANCER RES, V7, P1669
  • [8] Development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
    Burt, HM
    Zhang, XC
    Toleikis, P
    Embree, L
    Hunter, WL
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) : 161 - 171
  • [9] Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates
    Canal, Fabiana
    Vicent, Maria J.
    Pasut, Gianfranco
    Schiavon, Oddone
    [J]. JOURNAL OF CONTROLLED RELEASE, 2010, 146 (03) : 388 - 399
  • [10] CAPONE PM, 1984, JNCI-J NATL CANCER I, V72, P673