Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manaca)

被引：8
作者：
Barbosa, Daniela B. M.
Nascimento, Marcus V. M.
Lino, Roberta C.
Magalhaes, Marta R. [2 ]
Florentino, Iziara F.
Honorio, Tereza C. D.
Galdino, Pablinny M.
Bara, Maria Teresa F. [3 ]
de Paula, Jose R. [3 ]
Costa, Elson A. [1 ]
机构：
[1] Univ Fed Goias, Dept Ciencias Fisiol, Inst Ciencias Biol, BR-74001970 Goiania, Go, Brazil
[2] Pontificia Univ Catolica Goias, Ctr Estudos & Pesquisas Biol, Goiania, Go, Brazil
[3] Univ Fed Goias, Fac Farm, BR-74001970 Goiania, Go, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2012年 / 22卷 / 01期
关键词：
anti-inflammatory; antinociceptive; medicinal plant; phospholipase A(2); Spiranthera odoratissima; PHOSPHOLIPASE A(2); ETHANOLIC EXTRACT; NATURAL-PRODUCTS; MICE; ACID; FLAVONOIDS; INHIBITORS; DRUGS;
D O I：
10.1590/S0102-695X2011005000154
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A(2) activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A(2) activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A(2) activity.
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收藏
页码：137 / 143
页数：7
相关论文
共 52 条
[1]   Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms [J].
Borges, MH ;
Alves, DLF ;
Raslan, DS ;
Piló-Veloso, D ;
Rodrigues, VM ;
Homsi-Brandeburgo, MI ;
de Lima, ME .
JOURNAL OF ETHNOPHARMACOLOGY, 2005, 98 (1-2) :21-29
[2]  
BROOKS PM, 1991, NEW ENGL J MED, V324, P1716
[3]   Phospholipase A2 Biochemistry [J].
Burke, John E. ;
Dennis, Edward A. .
CARDIOVASCULAR DRUGS AND THERAPY, 2009, 23 (01) :49-59
[4]  
CATAODIAS LJ, 1999, BRAZ J VET RES ANIM, V36, P75
[5]   Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity [J].
Chandra, J. N. Narendra Sharath ;
Ponnappa, K. C. ;
Sadashiva, C. T. ;
Priya, B. S. ;
Nanda, B. L. ;
Gowda, T. Veerabasappa ;
Vishwanath, B. S. ;
Rangappa, K. S. .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (08) :787-800
[6]  
CONTRAN RS, 1999, PATOLOGIC BASIS DIS
[7]   Natural products from plant origin potentially usefull in the asthma therapy [J].
Correa, Maria Fernanda P. ;
de Melo, Giany O. ;
Costa, Sonia S. .
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2008, 18 :785-797
[8]   Quercetin as an inhibitor of snake venom secretory phospholipase A2 [J].
Cotrim, Camila Aparecida ;
Buzzo de Oliveira, Simone Cristina ;
Diz Filho, Eduardo B. S. ;
Fonseca, Fabiana Vieira ;
Baldissera, Lineu, Jr. ;
Antunes, Edson ;
Ximenes, Rafael Matos ;
Azul Monteiro, Helena Serra ;
Rabello, Marcelo Montenegro ;
Hernandes, Marcelo Zaldini ;
Toyama, Daniela de Oliveira ;
Toyama, Marcos Hikari .
CHEMICO-BIOLOGICAL INTERACTIONS, 2011, 189 (1-2) :9-16
[9]   Flavonoids: Potential Therapeutic Agents for the Inflammatory Process [J].
Coutinho, Marcela A. S. ;
Muzitano, Michelle F. ;
Costa, Sonia S. .
REVISTA VIRTUAL DE QUIMICA, 2009, 1 (03) :241-256
[10]   Structure and function of the selectin ligand PSGL-1 [J].
Cummings, RD .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1999, 32 (05) :519-528
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