Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming

被引:100
作者
LaRocca, Francesco [1 ]
Chiu, Stephanie J. [1 ]
McNabb, Ryan P. [1 ]
Kuo, Anthony N. [2 ]
Izatt, Joseph A. [1 ,2 ]
Farsiu, Sina [1 ,2 ]
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Ophthalmol, Durham, NC 27710 USA
关键词
OPTICAL COHERENCE TOMOGRAPHY; HIGH-SPEED; THICKNESS MEASUREMENTS; IN-VIVO; CURVATURE; TENSION;
D O I
10.1364/BOE.2.001524
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study of anterior segment diseases. However, manual segmentation is a time-consuming and subjective process. This paper presents an automatic approach for segmenting corneal layer boundaries in Spectral Domain Optical Coherence Tomography images using graph theory and dynamic programming. Our approach is robust to the low-SNR and different artifact types that can appear in clinical corneal images. We show that our method segments three corneal layer boundaries in normal adult eyes more accurately compared to an expert grader than a second grader-even in the presence of significant imaging outliers. (C)2011 Optical Society of America
引用
收藏
页码:1524 / 1538
页数:15
相关论文
共 29 条
[1]   Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation [J].
Chiu, Stephanie J. ;
Li, Xiao T. ;
Nicholas, Peter ;
Toth, Cynthia A. ;
Izatt, Joseph A. ;
Farsiu, Sina .
OPTICS EXPRESS, 2010, 18 (18) :19413-19428
[2]  
Dijkstra E. W., 1959, NUMER MATH, V1, P269
[3]   A Novel Algorithm for Extraction of the Layers of the Cornea [J].
Eichel, J. A. ;
Mishra, A. K. ;
Clausi, D. A. ;
Fieguth, P. W. ;
Bizheva, K. K. .
2009 CANADIAN CONFERENCE ON COMPUTER AND ROBOT VISION, 2009, :313-320
[4]   ISP Focus Issue: Optical Coherence Tomography (OCT) in Ophthalmology [J].
Fujimoto, James G. ;
Drexler, Wolfgang ;
Schuman, Joel S. ;
Hitzenberger, Christoph K. .
OPTICS EXPRESS, 2009, 17 (05) :3978-3979
[5]   Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images [J].
Garvin, Mona Kathryn ;
Abramoff, Michael David ;
Wu, Xiaodong ;
Russell, Stephen R. ;
Burns, Trudy L. ;
Sonka, Milan .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2009, 28 (09) :1436-1447
[6]   Automated segmentation of intraretinal layers from macular optical coherence tomography images [J].
Haeker, Mona ;
Sonka, Milan ;
Kardon, Randy ;
Shah, Vinay A. ;
Wu, Xiaodong ;
Abramoff, Michael D. .
MEDICAL IMAGING 2007: IMAGE PROCESSING, PTS 1-3, 2007, 6512
[7]   Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes [J].
Herndon, LW ;
Choudhri, SA ;
Cox, T ;
Damji, KF ;
Shields, MB ;
Allingham, RR .
ARCHIVES OF OPHTHALMOLOGY, 1997, 115 (09) :1137-1141
[8]   OPTICAL COHERENCE TOMOGRAPHY [J].
HUANG, D ;
SWANSON, EA ;
LIN, CP ;
SCHUMAN, JS ;
STINSON, WG ;
CHANG, W ;
HEE, MR ;
FLOTTE, T ;
GREGORY, K ;
PULIAFITO, CA ;
FUJIMOTO, JG .
SCIENCE, 1991, 254 (5035) :1178-1181
[9]   Swelling of the Human Cornea Revealed by High-Speed, Ultrahigh-Resolution Optical Coherence Tomography [J].
Hutchings, Natalie ;
Simpson, Trefford L. ;
Hyun, Chulho ;
Moayed, Alireza A. ;
Hariri, Sepideh ;
Sorbara, Luigina ;
Bizheva, Kostadinka .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (09) :4579-4584
[10]   MICROMETER-SCALE RESOLUTION IMAGING OF THE ANTERIOR EYE IN-VIVO WITH OPTICAL COHERENCE TOMOGRAPHY [J].
IZATT, JA ;
HEE, MR ;
SWANSON, EA ;
LIN, CP ;
HUANG, D ;
SCHUMAN, JS ;
PULIAFITO, CA ;
FUJIMOTO, JG .
ARCHIVES OF OPHTHALMOLOGY, 1994, 112 (12) :1584-1589