Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

被引：25
作者：
Hilvo, Mika [1 ]
Oresic, Matej [1 ]
机构：
[1] VTT Tech Res Ctr Finland, FI-02044 Espoo, Finland
来源：
CLINICAL LIPIDOLOGY | 2012年 / 7卷 / 02期
基金：
芬兰科学院;
关键词：
breast cancer; diagnostics; eicosanoids; glycolipids; lipid metabolism; lysophosphatidic acid; phospholipids; sphingolipids; therapeutics; FATTY-ACID SYNTHASE; ACETYL-COA CARBOXYLASE; ELEMENT-BINDING PROTEIN-1C; SPHINGOSINE KINASE TYPE-2; LYSOPHOSPHATIDIC ACID; SPHINGOLIPID METABOLISM; TUMOR PROGRESSION; GENE-EXPRESSION; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; EMISSION-TOMOGRAPHY;
D O I：
10.2217/CLP.12.10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During malignant transformation, the lipid metabolism of cells changes radically and therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid metabolism has been investigated at the gene and protein expression levels for several decades, but recent advances in lipidomics technology have also enabled the investigation of pathways at the level of molecular lipids. This review provides an overview of the changes of global lipid metabolism (i.e., fatty acid, phospholipid, eicosanoid and sphingolipid metabolism) in breast cancer, and discusses the diagnostic and therapeutic potential of these pathways.
引用
收藏
页码：177 / 188
页数：12
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