MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development

被引：17

作者：

Schneider, Edith ^{[1
]}

Staffas, Anna ^{[2
,3
]}

Roehner, Linda ^{[1
]}

Krowiorz, Kathrin ^{[1
]}

Heuser, Michael ^{[4
]}

Doehner, Konstanze ^{[1
]}

Bullinger, Lars ^{[1
]}

Doehner, Hartmut ^{[1
]}

Fogelstrand, Linda ^{[2
,3
]}

Rouhi, Arefeh ^{[1
]}

Kuchenbauer, Florian ^{[1
]}

Palmqvist, Lars ^{[2
,3
]}

机构：

[1] Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Clin Chem & Transfus Med, Gothenburg, Sweden

[3] Sahlgrens Univ Hosp, Dept Clin Chem, Gothenburg, Sweden

[4] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

来源：

EXPERIMENTAL HEMATOLOGY | 2016年 / 44卷 / 12期

基金：

加拿大健康研究院;

关键词：

MIR-155;

D O I：

10.1016/j.exphem.2016.08.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNA-155 (miR-155) is an oncogenic miRNA upregulated in various tumor types and leukemias and has been suggested as a potential drug target. Based on our previous work detecting high miR-155 levels in response to Meisl overexpression in a murine Hox leukemia model, we show here the relationship among HOXA9, MEIS1, and miR-155 levels in MLL-translocated acute myeloid leukemia (AML) patients. Using mouse bone marrow cells transformed by MLL-fusion genes expressing graduated levels of Meisl, we show a positive correlation between miR-155 and Meisl. However, using a miR-155-knockout mouse model, we show that the absence and the depletion of miR-155 have no effect on leukemia formation or progression. We also show for the first time that miR-155 levels are correlated with MLL translocations, but that miR-155 expression is dispensable for the formation of AML and has no effect on leukemia progression. Copyright (C) 2016 ISEH-International Society for Experimental Hematology. Published by Elsevier Inc.

引用

页码：1166 / 1171

页数：6

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