A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study

被引：34

作者：

Nakagawa-Senda, Hiroko ^{[1
,2
,10
]}

Hachiya, Tsuyoshi ^{[3
]}

Shimizu, Atsushi ^{[3
]}

Hosono, Satoyo ^{[1
]}

Oze, Isao ^{[4
]}

Watanabe, Miki ^{[1
]}

Matsuo, Keitaro ^{[4
,5
]}

Ito, Hidemi ^{[4
,5
]}

Hara, Megumi ^{[6
]}

Nishida, Yuichiro ^{[6
]}

Endoh, Kaori ^{[7
]}

Kuriki, Kiyonori ^{[7
]}

Katsuura-Kamano, Sakurako ^{[8
]}

Arisawa, Kokichi ^{[8
]}

Nindita, Yora ^{[9
]}

Ibusuki, Rie ^{[9
]}

Suzuki, Sadao ^{[10
]}

Hosono, Akihiro ^{[10
]}

Mikami, Haruo ^{[11
]}

Nakamura, Yohko ^{[11
]}

Takashima, Naoyuki ^{[12
]}

Nakamura, Yasuyuki ^{[13
]}

Kuriyama, Nagato ^{[14
]}

Ozaki, Etsuko ^{[14
]}

Furusyo, Norihiro ^{[15
]}

Ikezaki, Hiroaki ^{[15
]}

Nakatochi, Masahiro ^{[16
]}

Sasakabe, Tae ^{[2
]}

Kawai, Sayo ^{[2
]}

Okada, Rieko ^{[2
]}

Hishida, Asahi ^{[2
]}

Naito, Mariko ^{[2
]}

Wakai, Kenji ^{[2
]}

Momozawa, Yukihide ^{[17
]}

Kubo, Michiaki ^{[17
]}

Tanaka, Hideo ^{[1
]}

机构：

[1] Aichi Canc Ctr, Div Epidemiol & Prevent, Res Inst, Nagoya, Aichi, Japan

[2] Nagoya Univ, Dept Prevent Med, Grad Sch Med, Nagoya, Aichi, Japan

[3] Iwate Med Univ, Disaster Reconstruct Ctr, Iwate Tohoku Med Megabank Org, Div Biomed Informat Anal, Morioka, Iwate, Japan

[4] Aichi Canc Ctr, Div Mol & Clin Epidemiol, Res Inst, Nagoya, Aichi, Japan

[5] Nagoya Univ, Dept Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan

[6] Saga Univ, Dept Prevent Med, Fac Med, Saga, Japan

[7] Univ Shizuoka, Sch Food & Nutr Sci, Div Nutr Sci, Publ Hlth Lab, Shizuoka, Japan

[8] Tokushima Univ, Inst Biomed Sci, Dept Prevent Med, Grad Sch, Tokushima, Japan

[9] Kagoshima Univ, Dept Int Isl & Community Med, Grad Sch Med & Dent Sci, Kagoshima, Japan

[10] Nagoya City Univ, Dept Publ Hlth, Grad Sch Med Sci, Nagoya, Aichi, Japan

[11] Chiba Canc Ctr, Div Canc Prevent & Epidemiol, Chiba, Japan

[12] Shiga Univ Med Sci, Dept Publ Hlth, Shiga, Japan

[13] Ryukoku Univ, Dept Food Sci & Human Nutr, Fac Agr, Kyoto, Japan

[14] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, Kyoto, Japan

[15] Kyushu Univ, Dept Environm Med & Infect Dis, Fukuoka, Japan

[16] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Nagoya, Aichi, Japan

[17] RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

日本学术振兴会;

关键词：

HEPATOCELLULAR-CARCINOMA; ALCOHOL-CONSUMPTION; ALDH2; POLYMORPHISM; GENETIC-VARIATION; RISK; METAANALYSIS; VARIANTS; CANCER; CYP1A1-CYP1A2; DATABASE;

D O I：

10.1038/s41598-018-19914-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 x 10(-6)). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 x 10(-6)), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A metaanalysis of the discovery and replication populations, and the combined analysis using all subjects,

引用

页数：11

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