Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

被引：210

作者：

Tardiolo, Giuseppe ^{[1
]}

Bramanti, Placido ^{[1
]}

Mazzon, Emanuela ^{[1
]}

机构：

[1] Ctr Neurolesi Bonino Pulejo, IRCCS, Via Provinciale Palermo, I-98124 Messina, Italy

来源：

MOLECULES | 2018年 / 23卷 / 12期

关键词：

N-acetylcysteine; glutathione precursor; oxidative stress; Parkinson's disease; Alzheimer's disease; neuropathic pain; stroke; ACETYL-L-CYSTEINE; MILD COGNITIVE IMPAIRMENT; ISCHEMIA-REPERFUSION INJURY; NECROSIS-FACTOR-ALPHA; AGE-RELATED INCREASE; COMPLEX I ACTIVITY; INDUCED CELL-DEATH; D-ASPARTATE NMDA; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;

D O I：

10.3390/molecules23123305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson's and Alzheimer's disorders and in neuropathic pain and stroke.

引用

页数：20

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