D-optimal designs for logistic models with three and four parameters

被引:40
作者
Li, Gang [1 ]
Majumdar, Dibyen [2 ]
机构
[1] GlaxoSmithKline Inc, Collegeville, PA 19426 USA
[2] Univ Illinois, Chicago, IL 60607 USA
关键词
local optimality; D-optimality; nonlinear models; growth curve; T-system; saturated designs; minimally supported designs;
D O I
10.1016/j.jspi.2007.07.010
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Logistic functions are used in different applications, including biological growth studies and assay data analysis. Locally D-optimal designs for logistic models with three and four parameters are investigated. It is shown that these designs are minimally supported. Efficiencies are computed for equally spaced and uniform designs. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:1950 / 1959
页数:10
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