Phosphorylated α-Synuclein in Parkinson's Disease

被引：235

作者：

Wang, Yu ^{[1
,2
]}

Shi, Min ^{[1
]}

Chung, Kathryn A. ^{[3
]}

Zabetian, Cyrus P. ^{[4
,5
]}

Leverenz, James B. ^{[5
,6
,7
]}

Berg, Daniela ^{[8
,9
]}

Srulijes, Karin ^{[8
,9
]}

Trojanowski, John Q. ^{[10
]}

Lee, Virginia M. -Y. ^{[10
]}

Siderowf, Andrew D. ^{[11
]}

Hurtig, Howard ^{[11
]}

Litvan, Irene ^{[12
]}

Schiess, Mya C. ^{[13
]}

Peskind, Elaine R. ^{[6
,7
]}

Masuda, Masami ^{[14
]}

Hasegawa, Masato ^{[14
]}

Lin, Xiangmin ^{[1
]}

Pan, Catherine ^{[1
]}

Galasko, Douglas

Goldstein, David S. ^{[15
,16
]}

Jensen, Poul Henning ^{[17
]}

Yang, Hui ^{[1
]}

Cain, Kevin C. ^{[18
]}

Zhang, Jing ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98104 USA

[2] Huazhong Univ Sci & Technol, Dept Neurosurg, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA

[4] Vet Affairs Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA 98108 USA

[5] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98104 USA

[6] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98105 USA

[7] Vet Affairs Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA 98108 USA

[8] Univ Tubingen, Dept Neurodegenerat, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[9] Univ Tubingen, German Ctr Neurodegenerat Dis, D-72076 Tubingen, Germany

[10] Univ Penn, Sch Med, Dept Pathol & Lab Med, Inst Aging,Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[11] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19107 USA

[12] Univ Louisville, Sch Med, Div Movement Disorders, Louisville, KY 40202 USA

[13] Univ Texas Hlth Sci Ctr, Dept Neurol, Houston, TX 77030 USA

[14] Tokyo Metropolitan Inst Med Sci, Dept Neuropathol & Cell Biol, Setagaya Ku, Tokyo 1568585, Japan

[15] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[16] NINDS, Clin Neurocardiol Sect, Community Networks Program, Div Intramural Res,NIH, Bethesda, MD 20892 USA

[17] Aarhus Univ, Dept Med Chem, DK-8000 Aarhus C, Denmark

[18] Univ Washington, Dept Biostat, Seattle, WA 98105 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 121期

关键词：

PROGRESSIVE SUPRANUCLEAR PALSY; MULTIPLE-SYSTEM ATROPHY; HUMAN CEREBROSPINAL-FLUID; RICHARDSONS-SYNDROME; CONSENSUS STATEMENT; ALZHEIMERS-DISEASE; PSP-PARKINSONISM; LEWY BODIES; DIAGNOSIS; NEURODEGENERATION;

D O I：

10.1126/scitranslmed.3002566

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphorylated alpha-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total alpha-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of similar to 600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total alpha-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.

引用

页数：8

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