Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing

被引：401
作者：
Chi, Junjie [1 ,2 ,3 ]
Zhang, Xiaoxuan [1 ,3 ]
Chen, Canwen [1 ]
Shao, Changmin [3 ]
Zhao, Yuanjin [1 ,3 ]
Wang, Yongan [2 ]
机构：
[1] Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Clin Lab, Nanjing 210008, Peoples R China
[2] Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
[3] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Peoples R China
来源：
BIOACTIVE MATERIALS | 2020年 / 5卷 / 02期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Microneedle; Chitosan; Drug delivery; Wound healing; Patch; SCAFFOLDS;
D O I：
10.1016/j.bioactmat.2020.02.004
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing. In this paper, we develop a biomass chitosan microneedle array (CSMNA) patch integrated with smart responsive drug delivery for promoting wound healing. Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing. Besides, the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch. Also, vascular endothelial growth factor (VEGF) is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel. Therefore, the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds. It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition, collagen deposition, angiogenesis, and tissue regeneration during the wound closure. Thus, this versatile CSMNA patch is potentially valuable for wound healing in clinical applications.
引用
收藏
页码：253 / 259
页数：7
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