Direct Short-Term Cytotoxic Effects of BIBR 1532 on Acute Promyelocytic Leukemia Cells Through Induction of p21 Coupled with Downregulation of c-Myc and hTERT Transcription

被引：32

作者：

Bashash, D. ^{[1
,2
]}

Ghaffari, S. H. ^{[1
]}

Zaker, F. ^{[2
]}

Hezave, K. ^{[2
]}

Kazerani, M. ^{[2
]}

Ghavamzadeh, A. ^{[1
]}

Alimoghaddam, K. ^{[1
]}

Mosavi, S. A. ^{[1
]}

Gharehbaghian, A. ^{[3
]}

Vossough, P. ^{[4
]}

机构：

[1] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Fac Allied Med, Dept Hematol, Tehran, Iran

[3] Shihid Beheshti Univ Med Sci, Fac Allied Med, Dept Lab Med, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Hematol, Hazrate Aliasghar Childrens Hosp, Tehran, Iran

来源：

CANCER INVESTIGATION | 2012年 / 30卷 / 01期

关键词：

BIBR; 1532; Telomerase; hTERT; c-Myc; p21; APL; NB4; TELOMERASE ACTIVITY; HUMAN CANCER; INDUCED APOPTOSIS; INHIBITION; DEATH; THERAPEUTICS; DYSFUNCTION; SURVIVAL; PATHWAY; GROWTH;

D O I：

10.3109/07357907.2011.629378

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is characterized by specific 15; 17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct short-term growth suppressive effect in a concentration-dependent manner probably through downregulation of c-Myc and hTERT expression. Our results also suggest that induction of p21 and subsequent disturbance of Bax/Bcl-2 balanced ratio as well as decreased telomerase activity may be rational mechanisms for the potent/direct short-term cytotoxicity of high doses of BIBR1532 against NB4 cells.

引用

页码：57 / 64

页数：8

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