The effect of supplemental vitamins and minerals on the development of prostate cancer: a systematic review and meta-analysis

被引:49
作者
Stratton, Julie [1 ]
Godwin, Marshall [1 ]
机构
[1] Mem Univ Newfoundland, Primary Healthcare Res Unit, Dept Family Med, St John, NF A1B 3V6, Canada
关键词
Family medicine; meta-analysis; nutrition; prostate cancer; systematic review; urology; vitamin supplementation; BETA-CAROTENE; LARGE COHORT; RISK; PREVENTION; MORTALITY; SELENIUM; HEALTH; DIET; MEN;
D O I
10.1093/fampra/cmq115
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. Vitamin supplementation is used for many purposes with mainly alleged benefits. One of these is the use of various vitamins for the prevention of prostate cancer. Methods. We conducted a systematic review and meta-analysis on this topic. Pubmed, Embase and the Cochrane Database were searched; as well, we hand searched the references in key articles. Randomized controlled trials (RCTs), cohort studies and case-control studies were included. The review assessed the effect of supplemental vitamins on the risk of prostate cancer and on disease severity and death in men with prostate cancer. Results. Fourteen articles were included in the final assessment. Individually, a few of these studies showed a relationship between the ingestion of supplemental vitamins or minerals and the incidence or severity of prostate cancer, especially in smokers. However, neither the use of multivitamin supplementation nor the use of individual vitamin/mineral supplementation affected the overall occurrence of prostate cancer or the occurrence of advanced/metastatic prostate cancer or death from prostate cancer when the results of the studies were combined in a meta-analysis. We also conducted several sensitivity analyses by running meta-analysis using just the higher quality studies and just the RCTs. There were still no associations found. Conclusions. There is no convincing evidence that the use of supplemental multivitamins or any specific vitamin affects the occurrence or severity of prostate cancer. There was high heterogeneity among the studies so it is possible that unidentified subgroups may benefit or be harmed by the use of vitamins.
引用
收藏
页码:243 / 252
页数:10
相关论文
共 17 条
[11]   Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial [J].
Meyer, F ;
Galan, P ;
Douville, P ;
Bairati, I ;
Kegle, P ;
Bertrais, S ;
Estaquio, C ;
Hercberg, S .
INTERNATIONAL JOURNAL OF CANCER, 2005, 116 (02) :182-186
[12]  
Moher D, 2009, ANN INTERN MED, V151, P264, DOI [10.7326/0003-4819-151-4-200908180-00135, 10.1136/bmj.b2700, 10.1371/journal.pmed.1000097, 10.1136/bmj.i4086, 10.1016/j.ijsu.2010.02.007, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.b2535, 10.1186/2046-4053-4-1]
[13]   Vitamin E and selenium supplementation and risk of prostate cancer in the vitamins and lifestyle (VITAL) study cohort [J].
Peters, Ulrike ;
Littman, Alyson J. ;
Kristal, Alan R. ;
Patterson, Ruth E. ;
Potter, John D. ;
White, Emily .
CANCER CAUSES & CONTROL, 2008, 19 (01) :75-87
[14]  
Rodriguez C, 2004, CANCER EPIDEM BIOMAR, V13, P378
[15]   Use of multivitamins and prostate cancer mortality in a large cohort of US men [J].
Stevens, VL ;
McCullough, ML ;
Diver, WR ;
Rodriguez, C ;
Jacobs, EJ ;
Thun, MJ ;
Calle, EE .
CANCER CAUSES & CONTROL, 2005, 16 (06) :643-650
[16]   Supplemental and dietary vitamin E intakes and risk of prostate cancer in a large prospective study [J].
Wright, Margaret E. ;
Weinstein, Stephanie J. ;
Lawson, Karla A. ;
Albanes, Demetrius ;
Subar, Amy F. ;
Dixon, L. Beth ;
Mouw, Traci ;
Schatzkin, Arthur ;
Leitzmann, Michael F. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (06) :1128-1135
[17]   Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study [J].
Zhang, Yuqing ;
Coogan, Patricia ;
Palmer, Julie R. ;
Strom, Brian L. ;
Rosenberg, Lynn .
CANCER CAUSES & CONTROL, 2009, 20 (05) :691-698