Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

被引：131

作者：

Ju, Yi

Cui, Jiwei

Muellner, Markus

Suma, Tomoya

Hu, Ming

Caruso, Frank ^{[1
]}

机构：

[1] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3010, Australia

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

DRUG-DELIVERY; MULTIFUNCTIONAL COATINGS; PROTEIN ENCAPSULATION; POLYPHENOL; POLYMER; MICROCAPSULES; PARTICLES; COMPLEXES; FILMS;

D O I：

10.1021/bm5017139

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability).

引用

收藏

页码：807 / 814

页数：8

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