The role of the kidney in salt-sensitive hypertension

被引:30
|
作者
Trepiccione, Francesco [1 ]
Zacchia, Miriam [1 ]
Capasso, Giovambattista [1 ]
机构
[1] Univ Naples 2, Fac Med, Dept Internal Med, Chair Nephrol, I-80131 Naples, Italy
关键词
Hypertension; Salt; Milan hypertensive strain; NKCC2; NCC; Thiazide; BLOOD-PRESSURE; UP-REGULATION; RATS; CHLORIDE; COTRANSPORTER; TRANSPORT; ALPHA; EXPRESSION; VESICLES; ION;
D O I
10.1007/s10157-011-0489-y
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Primary hypertension is one of the leading risk factors for cardiovascular disease. Although the pathogenesis is not completely understood, an imbalance of sodium and chloride homeostasis seems to be relevant both in the induction and in the maintenance of salt-sensitive hypertension. Besides individual renal phenotypes, salt intake is one of the most important environmental determinants of this condition. The Milan hypertensive strain (MHS) of rats is an interesting model to investigate the molecular mechanisms underling the development of salt-sensitive hypertension. In young MHS rats, hypertension is anticipated by a phase of increased salt reabsorption localized along the medullary thick ascending limb associated with the up-regulation of the apical sodium-potassium-chloride cotransporter (NKCC2). Later, the frank hypertensive status of adult MHS rats is accompanied by the activation of the luminal and basal lateral transporters of sodium chloride (NaCl) in the distal convoluted tubule (DCT). Several lines of evidence have proven the key role of DCT in the maintenance of hypertension in MHS rats; more importantly, hypertensive patients carrying a mutation of alpha-adducin (resembling the MHS model) have a high sensitivity to thiazides, suggesting that the Na+-Cl- cotransporter also plays a pivotal role in humans.
引用
收藏
页码:68 / 72
页数:5
相关论文
共 50 条
  • [31] Intravital imaging of the kidney in a rat model of salt-sensitive hypertension
    Endres, Bradley T.
    Sandoval, Ruben M.
    Rhodes, George J.
    Campos-Bilderback, Silvia B.
    Kamocka, Malgorzata M.
    McDermott-Roe, Christopher
    Staruschenko, Alexander
    Molitoris, Bruce A.
    Geurts, Aron M.
    Palygin, Oleg
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2017, 313 (02) : F163 - F173
  • [32] Metabolomic Kidney Input and Output Analyses in Salt-Sensitive Hypertension
    Hoffmann, Brian R.
    Shimada, Satoshi
    Greene, Andrew S.
    Liang, Mingyu
    Dash, Ranjan
    Cowley, Allen
    FASEB JOURNAL, 2022, 36
  • [33] Salt-sensitive hypertension - Reply
    Johnson, RJ
    Herrera-Acosta, J
    Schreiner, GF
    Rodriguez-Iturbe, B
    NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (06): : 448 - 449
  • [34] The brain and salt-sensitive hypertension
    Frans H. H. Leenen
    Marcel Ruzicka
    Bing S. Huang
    Current Hypertension Reports, 2002, 4 : 129 - 135
  • [35] Genetics of salt-sensitive hypertension
    Pasquale Strazzullo
    Ferruccio Galletti
    Current Hypertension Reports, 2007, 9
  • [36] Genetics of salt-sensitive hypertension
    Strazzullo, Pasquale
    Galletti, Ferruccio
    CURRENT HYPERTENSION REPORTS, 2007, 9 (01) : 25 - 32
  • [37] Lysine and salt-sensitive hypertension
    Dissanayake, Lashodya V.
    Palygin, Oleg
    Staruschenko, Alexander
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2024, 33 (04): : 441 - 446
  • [38] Genetics of Salt-Sensitive Hypertension
    Sanada, Hironobu
    Jones, John E.
    Jose, Pedro A.
    CURRENT HYPERTENSION REPORTS, 2011, 13 (01) : 55 - 66
  • [39] Mechanisms of Salt-Sensitive Hypertension
    Luzardo, Leonella
    Noboa, Oscar
    Boggia, Jose
    CURRENT HYPERTENSION REVIEWS, 2015, 11 (01) : 14 - 21
  • [40] Genetics of Salt-Sensitive Hypertension
    Hironobu Sanada
    John E. Jones
    Pedro A. Jose
    Current Hypertension Reports, 2011, 13 : 55 - 66