Mass spectrometry-based lipid analysis and imaging

被引：8
|
作者：
Pathmasiri, Koralege C. [1 ]
Nguyen, Thu T. A. [1 ]
Khamidova, Nigina [1 ]
Cologna, Stephanie M. [1 ,2 ]
机构：
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Univ Illinois, Lab Integrated Neurosci, Chicago, IL 60607 USA
来源：
NEW METHODS AND SENSORS FOR MEMBRANE AND CELL VOLUME RESEARCH | 2021年 / 88卷
关键词：
DESORPTION ELECTROSPRAY-IONIZATION; TISSUE CHEMICAL DERIVATIZATION; SINGLE LASER SHOT; TOF-MS ANALYSIS; DOUBLE-BOND; SAMPLE PREPARATION; MALDI-MSI; 2,5-DIHYDROXYBENZOIC ACID; QUANTITATIVE-ANALYSIS; SPATIAL SEGMENTATION;
D O I：
10.1016/bs.ctm.2021.10.005
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Mass spectrometry imaging (MSI) is a powerful tool for in situ mapping of analytes across a sample. With growing interest in lipid biochemistry, the ability to perform such mapping without antibodies has opened many opportunities for MSI and lipid analysis. Herein, we discuss the basics of MSI with particular emphasis on MALDI mass spectrometry and lipid analysis. A discussion of critical advancements as well as protocol details are provided to the reader. In addition, strategies for improving the detection of lipids, as well as applications in biomedical research, are presented.
引用
收藏
页码：315 / 357
页数：43
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