The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase

被引：32
作者：
Kim, Mi-Yeon [1 ]
Jung, Jane [1 ]
Mo, Jung-Soon [1 ]
Ann, Eun-Jung [1 ]
Ahn, Ji-Seon [1 ]
Yoon, Ji-Hye [1 ]
Park, Hee-Sae [1 ]
机构：
[1] Chonnam Natl Univ, Sch Biol Sci & Technol, Hormone Res Ctr, Kwangju 500757, South Korea
来源：
EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 17期
关键词：
Notch1-IC; Jagged-1 intracellular domain; Fbw7; RBP-Jk; Mastermind; GAMMA-SECRETASE INHIBITORS; CIS-INHIBITION; PRESOMITIC MESODERM; PROTEIN-DEGRADATION; NEGATIVE REGULATOR; SIGNALING PATHWAY; DOWN-REGULATION; TARGET GENES; DROSOPHILA; DELTA;
D O I：
10.1016/j.yexcr.2011.07.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Notch signaling involves the proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands. Jagged-1 also undergoes proteolytic cleavage by gamma-secretase and releases an intracellular fragment. In this study, we have demonstrated that the Jagged-1 intracellular domain (JICD) inhibits Notch] signaling via a reduction in the protein stability of the Notch1 intracellular domain (Notch1-IC). The formation of the Notch1-IC-RBP-Jk-Mastermind complex is prevented in the presence of JICD, via a physical interaction. Furthermore, JICD accelerates the protein degradation of Notch1-IC via Fbw7-dependent proteasomal pathway. These results indicate that JICD functions as a negative regulator in Notch1 signaling via the promotion of Notch1-IC degradation. C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：2438 / 2446
页数：9
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