Antiarrhythmic agents based on diterpenoid alkaloids

被引：27

作者：

Yunusov, M. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450075, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2011年 / 60卷 / 04期

关键词：

diterpenoid alkaloids; antiarrhythmic agents; arrhythmogenic agents; structure-activity relationships;

D O I：

10.1007/s11172-011-0098-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diterpenoid alkaloids comprise a large group of natural compounds produced by the plants of the genera Aconitum and Delphinium. Some of these compounds were found to manifest valuable pharmacological properties, including the unique antiarrhythmic activity. Allapinine (derived from the alkaloid lappaconitine) was approved as a drug. The investigation of the structure-activity relationship revealed structural elements responsible for the arrhythmogenic and antiarrhythmic properties.

引用

页码：633 / 638

页数：6

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