An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination A Case Report

被引：22

作者：

Ghincea, Alexander ^{[1
]}

Ryu, Changwan ^{[1
]}

Herzog, Erica L. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT 06510 USA

来源：

CHEST | 2022年 / 161卷 / 02期

关键词：

acute exacerbation; BNT162b2 mRNA COVID-19 vaccine; COVID-19; idiopathic pulmonary fibrosis; interstitial lung disease;

D O I：

10.1016/j.chest.2021.07.2160

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scar tissue formation. An acute exacerbation of IPF (AE-IPF) is a clinically significant respiratory decompensation that accounts for a significant proportion of IPF-related morbidity and mortality. AE-IPF can be idiopathic or associated with pulmonary embolism, infection, aspiration, surgery, and drug toxicity. In this novel case report, we describe a potential association between AE-IPF and BNT162b2 mRNA COVID-19 vaccination that was successfully treated with a short course of glucocorticoids. While our aim is to raise awareness for this yet to-be-described adverse event, immunization against vaccine-preventable disease remains widely recommended in vulnerable patients with chronic lung disease such as IPF. CHEST 2022; 161(2):e71-e73

引用

页码：E71 / E73

页数：3

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[8]

Vaccines that Protect Against Infectious Respiratory Diseases, LUNG HLTH DIS VACC 2

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