Tobacco-specific carcinogen 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK) activating ERK1/2 MAP kinases and stimulating proliferation of human mammary epithelial cells

被引：2
作者：
Chen Zhi-bo
An Yang
Wang Zhe
Zhang Bo-xun
Liu Lan-ying [1 ]
机构：
[1] Jilin Univ, Coll Life Sci, Changchun 130021, Peoples R China
[2] Qiqihar Univ, Coll Life Sci & Engn, Qiqihar 161000, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Dept Internal Med Digest, Changchun 130033, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2007年 / 23卷 / 01期
关键词：
mammary epithelial cells; NNK; ERK MAPK; nicotinic receptor nAchR; tyrosine kinase; signaling pathway; carcinogen; cell proliferation;
D O I：
10.1016/S1005-9040(07)60015-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cigarette smoking is correlated with the development of various cancers. 4-(Methylnitrosoaxnino)-1-(3-pyridyl)-1-butanone(NNK) is one of the major tobacco-specific carcinogens in the cigarette smoke, which increases the risk of breast cancer. In the present study, it was demonstrated that NNK rapidly activated ERK1 and ERK2 MAP kinases in human normal mammary epithelial cells. It was found that there are two different routes for the activation of ERK1/2 with NNK. One is from nicotinic receptor nAchR to MEK1/2, and the other is from tyrosine kinase containing receptor to MEK1/2. The tobacco-specific carcinogen NNK shows a strong proliferative effect on normal human mammary epithelial cells and cancer mammary epithelial cells.
引用
收藏
页码：76 / 80
页数：5
相关论文
共 23 条
[1]   Central role of fibroblast α3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine [J].
Arredondo, J ;
Hall, LL ;
Ndoye, A ;
Nguyen, VT ;
Chernyavsky, AI ;
Bercovich, D ;
Orr-Urtreger, A ;
Beaudet, AL ;
Grando, SA .
LABORATORY INVESTIGATION, 2003, 83 (02) :207-225
[2]   The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through β-adrenergic transactivation of EGF receptors [J].
Askari, MDF ;
Tsao, MSS ;
Schuller, HM .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2005, 131 (10) :639-648
[3]   Alcohol, tobacco and breast cancer -: collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease [J].
Beral, V ;
Hamajima, N ;
Hirose, K ;
Rohan, T ;
Calle, EE ;
Heath, CW ;
Coates, RJ ;
Liff, JM ;
Talamini, R ;
Chantarakul, N ;
Koetsawang, S ;
Rachawat, D ;
Morabia, A ;
Schuman, L ;
Stewart, W ;
Szklo, M ;
Bain, C ;
Schofield, F ;
Siskind, V ;
Band, P ;
Coldman, AJ ;
Gallagher, RP ;
Hislop, TG ;
Yang, P ;
Kolonel, LM ;
Nomura, AMY ;
Hu, J ;
Johnson, KC ;
Mao, Y ;
De Sanjose, S ;
Lee, N ;
Marchbanks, P ;
Ory, HW ;
Peterson, HB ;
Wilson, HG ;
Wingo, PA ;
Ebeling, K ;
Kunde, D ;
Nishan, P ;
Hopper, JL ;
Colditz, G ;
Gajalakshmi, V ;
Martin, N ;
Pardthaisong, T ;
Solpisornkosol, S ;
Theetranont, C ;
Boosiri, B ;
Chutivongse, S ;
Jimakorn, P ;
Virutamasen, P .
BRITISH JOURNAL OF CANCER, 2002, 87 (11) :1234-1245
[4]   The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling [J].
Dunn, KL ;
Espino, PS ;
Drobic, B ;
He, SH ;
Davie, JR .
BIOCHEMISTRY AND CELL BIOLOGY, 2005, 83 (01) :1-14
[5]   The MAPK signalling pathways and colorectal cancer [J].
Fang, JY ;
Richardson, BC .
LANCET ONCOLOGY, 2005, 6 (05) :322-327
[6]   Signalling pathways involved in nicotine regulation of apoptosis human lung cancer cells [J].
Heusch, WL ;
Maneckjee, R .
CARCINOGENESIS, 1998, 19 (04) :551-556
[7]   Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation [J].
Ho, YS ;
Chen, CH ;
Wang, YJ ;
Pestell, RG ;
Albanese, C ;
Chen, RJ ;
Chang, MC ;
Jeng, JH ;
Lin, SY ;
Liang, YC ;
Tseng, H ;
Lee, WS ;
Lin, JK ;
Chu, JS ;
Chen, LC ;
Lee, CH ;
Tso, WL ;
Lai, YC ;
Wu, CH .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2005, 205 (02) :133-148
[8]   Accumulating evidence on passive and active smoking and breast cancer risk [J].
Johnson, KC .
INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (04) :619-628
[9]   BREAST-CANCER EPIDEMIOLOGY - SUMMARY AND FUTURE-DIRECTIONS [J].
KELSEY, JL .
EPIDEMIOLOGIC REVIEWS, 1993, 15 (01) :256-263
[10]   CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].
LAEMMLI, UK .
NATURE, 1970, 227 (5259) :680-+
123