Lineage Reprogramming A Promising Road for Pancreatic β Cell Regeneration

被引：30

作者：

Wei, Rui ^{[1
]}

Hong, Tianpei ^{[1
]}

机构：

[1] Peking Univ, Hosp 3, Dept Endocrinol & Metab, Beijing 100191, Peoples R China

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 03期

关键词：

INSULIN-PRODUCING CELLS; ISLET-LIKE CELLS; IN-VITRO; EPITHELIAL-CELLS; DUCTAL CELLS; TRANSCRIPTION FACTOR; EXOCRINE PANCREAS; PROGENITOR CELLS; ENDOCRINE-CELLS; SMALL MOLECULES;

D O I：

10.1016/j.tem.2016.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell replacement therapy is a promising method to restore pancreatic beta cell function and cure diabetes. Distantly related cells (fibroblasts, keratinocytes, and muscle cells) and developmentally related cells (hepatocytes, gastrointestinal, and pancreatic exocrine cells) have been successfully reprogrammed into beta cells in vitro and in vivo. However, while some reprogrammed beta cells bear similarities to bona fide beta cells, others do not develop into fully functional beta cells. Here we review various strategies currently used for beta cell reprogramming, including ectopic expression of specific transcription factors associated with islet development, repression of maintenance factors of host cells, regulation of epigenetic modifications, and microenvironmental changes. Development of simple and efficient reprogramming methods is a key priority for developing fully functional beta cells suitable for cell replacement therapy.

引用

页码：163 / 176

页数：14

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