Facile synthesis of 5,6,7,8-tetrahydropyrimido [4,5-b] quinoline derivatives

被引：49

作者：

Elkholy, Yehya Mahmoud ^{[1
]}

Morsy, Mohamed Abdelhamed ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

MOLECULES | 2006年 / 11卷 / 11期

关键词：

tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure;

D O I：

10.3390/11110890

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Amino-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2-benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.

引用

页码：890 / 903

页数：14

共 32 条

[1] Synthesis and radiation stability of some new biologically active hydroquinoline and pyrimido[4,5-b]quinoline derivatives [J].