Is there a link between insulin resistance and inflammatory activation in preeclampsia?

被引：12

作者：

Scioscia, Marco ^{[1
,2
]}

Greco, Pantaleo ^{[3
]}

Selvaggi, Luigi E. ^{[4
]}

Rademacher, Thomas W. ^{[5
]}

机构：

[1] Sacro Cuore Don Calabria Gen Hosp, Dept Obstet & Gynaecol, Verona, Italy

[2] Tor Vergata Univ, Dept Perinatal Med, Rome, Italy

[3] Univ Foggia, Div Obstet & Gynaecol, Dept Surg Sci, Foggia, Italy

[4] Univ Med Sci Bari, Dept Gynaecol Obstet & Neonatol, Bari, Italy

[5] Royal Free & Univ Coll Med Sch, Dept Immunol & Mol Pathol, Mol Med Unit, Sch Med, London, England

来源：

MEDICAL HYPOTHESES | 2009年 / 73卷 / 05期

关键词：

PHOSPHOGLYCAN P-TYPE; INOSITOL PHOSPHOGLYCANS; OXIDATIVE STRESS; MIRROR SYNDROME; AMNIOTIC-FLUID; PREGNANCY; FETAL; REVERSAL; GLUCOSE; PHOSPHORYLATION;

D O I：

10.1016/j.mehy.2009.01.057

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Preeclampsia is a severe complication of human pregnancy and an insulin resistant state has been demonstrated in this multisystem disorder, although its bases remain unclear. Inositol phosphoglycans P-type belongs to a family of putative insulin mediators and was described to exert many insulin-like effects on lipid and glucose metabolism. A definite association between this molecule and preeclampsia was reported. The systemic inflammatory activation that occurs in preeclampsia as a consequence of the immunological dysfunction can exacerbate placental insulin resistance leading to an over-expression of P-IPG as a counterregulatory mechanism to insulin resistance. Besides, the lipidic form of P-IPG was reported to be similar to endotoxins, and may represent the link between insulin resistance, systemic inflammation and increased angiogenic factors. In this article we propose a new working theory on insulin resistance and preeclampsia. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：813 / 817

页数：5

共 42 条

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