The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins

被引：19

作者：

Berends, Elsa ^{[1
]}

Scholtmeijer, Karin ^{[1
]}

Wosten, Han A. B. ^{[1
]}

Bosch, Dirk ^{[1
,2
]}

Lugones, Luis G. ^{[1
]}

机构：

[1] Univ Utrecht, Inst Biomembranes, Mol Microbiol & Kluyver Ctr Genom Ind Fermentat, NL-3584 CH Utrecht, Netherlands

[2] Univ Wageningen & Res Ctr, NL-6708 PB Wageningen, Netherlands

来源：

TRENDS IN MICROBIOLOGY | 2009年 / 17卷 / 10期

关键词：

FILAMENTOUS FUNGI; BASIDIOMYCETE; LACCASE; GLYCANS; ROLES;

D O I：

10.1016/j.tim.2009.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. This requires cost-effective production platforms that display correct and homogeneous N-glycosylation. Based on recent results, we propose to use mushroom-forming basidiomycetes for the production of N-glycosylated therapeutic: proteins.

引用

收藏

页码：439 / 443

页数：5

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