Advances in cervical cancer pharmacotherapies

被引：20

作者：

Markman, Maurie ^{[1
]}

机构：

[1] Canc Treatment Ctr Amer, Eastern Reg Med Ctr, Philadelphia, PA 19124 USA

来源：

EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2014年 / 7卷 / 02期

关键词：

bevacizumab; cervical cancer; chemotherapy of cervix cancer; cisplatin; concurrent chemoradiation; GYNECOLOGIC-ONCOLOGY-GROUP; GEMCITABINE PLUS CISPLATIN; SQUAMOUS-CELL CARCINOMA; PHASE-II TRIAL; CONCURRENT GEMCITABINE; ADJUVANT GEMCITABINE; RADIATION-THERAPY; RANDOMIZED-TRIAL; OPEN-LABEL; DEFINITIVE RADIOTHERAPY;

D O I：

10.1586/17512433.2014.884924

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While widely employed in the management of cervical cancer, the overall utility of systemic anti-neoplastic agents in this clinical setting is quite modest. Cisplatin, the single most studied agent, is currently administered concurrently with external beam radiation as a component of "standard-of-care" in the management of locally advanced cervical cancer. Cisplatin (or carboplatin) combined with paclitaxel is the most commonly utilized regimen in the metastatic/recurrent disease setting (assuming the absence of evidence the cancer is resistant to platinum agents). Recently reported phase 3 trial data have demonstrated that the addition of bevacizumab to either a cisplatin/paclitaxel or paclitaxel/topotecan chemotherapy regimen improves overall survival in metastatic/recurrent cervical cancer.

引用

页码：219 / 223

页数：5

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