Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

被引：121
作者：
Wu, Bill X. [1 ]
Clarke, Christopher J. [1 ]
Hannun, Yusuf A. [1 ]
机构：
[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA
来源：
NEUROMOLECULAR MEDICINE | 2010年 / 12卷 / 04期
关键词：
Ceramide; Bioactive lipids; Neutral sphingomyelinase; Sphingolipid; SM; nSMase2; NECROSIS-FACTOR-ALPHA; NIEMANN-PICK-DISEASE; AMYLOID-BETA-PEPTIDE; PHOSPHOSPHINGOLIPID-PHOSPHOLIPASE-C; NITRIC-OXIDE SYNTHASE; LUNG EPITHELIAL-CELLS; P55; TNF-RECEPTOR; OXIDATIVE STRESS; SUBCELLULAR-LOCALIZATION; MEDIATED ACTIVATION;
D O I：
10.1007/s12017-010-8120-z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg2+-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.
引用
收藏
页码：320 / 330
页数：11
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