Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)

被引：18

作者：

Raji-amirhasani, Alireza ^{[1
]}

Khaksari, Mohammad ^{[1
]}

Darvishzadeh Mahani, Fatemeh ^{[2
]}

Hajializadeh, Zahra ^{[3
]}

机构：

[1] Kerman Univ Med Sci, Endocrinol & Metab Res Ctr, Kerman, Iran

[2] Kerman Univ Med Sci, Cardiovasc Res Ctr, Kerman, Iran

[3] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman, Iran

来源：

CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2021年 / 25卷 / 08期

关键词：

Acute kidney injury; SIRT1; Activators of SIRT1; Histone acetylation; NF-KAPPA-B; RENAL ISCHEMIA/REPERFUSION INJURY; TUBULAR EPITHELIAL-CELLS; INDUCED CD40 EXPRESSION; COLLECTING DUCT CELLS; EXTRACELLULAR VESICLES; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDATIVE PATHWAY; INDUCED NEPHROPATHY;

D O I：

10.1007/s10157-021-02057-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) is a complex disorder and a clinical condition characterized by acute reduction in renal function. If AKI is not treated, it can lead to chronic kidney disease, which is associated with a high risk of death. SIRT1 (silent information regulator 1) is an NAD-dependent deacetylase. This enzyme is responsible for the processes of DNA repair or recombination, chromosomal stability, and gene transcription. This enzyme also plays a protective role in many diseases, including AKI. In this study, we review the mechanisms that mediate the protective effects of SIRT1 on AKI, including SIRT1 activators.

引用

页码：807 / 821

页数：15

共 125 条

[1] Improving outcomes from acute kidney injury: report of an initiative [J].

Bagga, Arvind ;

Bakkaloglu, Aysin ;

Devarajan, Prasad ;

Mehta, Ravindra L. ;

Kellum, John A. ;

Shah, Sudhir V. ;

Molitoris, Bruce A. ;

Ronco, Claudio ;

Warnock, David G. ;

Joannidis, Michael ;

Levin, Adeera .

PEDIATRIC NEPHROLOGY, 2007, 22 (10) :1655-1658

[2] Melatonin prevents acute kidney injury in severely burned rats via the activation of SIRT1 [J].

Bai, Xiao-Zhi ;

He, Ting ;

Gao, Jian-Xin ;

Liu, Yang ;

Liu, Jia-Qi ;

Han, Shi-Chao ;

Li, Yan ;

Shi, Ji-Hong ;

Han, Jun-Tao ;

Tao, Ke ;

Xie, Song-Tao ;

Wang, Hong-Tao ;

Hu, Da-Hai .

SCIENTIFIC REPORTS, 2016, 6

[3] Exosomes: Therapy delivery tools and biomarkers of diseases [J].

Barile, Lucio ;

Vassalli, Giuseppe .

PHARMACOLOGY & THERAPEUTICS, 2017, 174 :63-78

[4] Pathophysiology of Acute Kidney Injury [J].

Basile, David P. ;

Anderson, Melissa D. ;

Sutton, Timothy A. .

COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1303-1353

[5] Of inflammasomes and pathogens - sensing of microbes by the inflammasome [J].

Bauernfeind, Franz ;

Hornung, Veit .

EMBO MOLECULAR MEDICINE, 2013, 5 (06) :814-826

[6] Apoptotic Cell-Derived extracellular vesicles: More Than Just Debris [J].

Caruso, Sarah ;

Poon, Ivan K. H. .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[7] SIRT1 Mediates Effects of FGF21 to Ameliorate Cisplatin-Induced Acute Kidney Injury [J].

Chen, Qiongzhen ;

Ma, Junfeng ;

Yang, Xiaoning ;

Li, Qinyao ;

Lin, Zhuofeng ;

Gong, Fanghua .

FRONTIERS IN PHARMACOLOGY, 2020, 11

[8] Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction [J].

Chen, Tao ;

Guo, Zai-pei ;

Wang, Lin ;

Qin, Sha ;

Cao, Na ;

Li, Meng-meng ;

Jia, Rui-zhen ;

Wang, Ting-ting .

EXPERIMENTAL DERMATOLOGY, 2013, 22 (07) :453-457

[9] Regulation of SIRT1 by MicroRNAs [J].

Choi, Sung-E ;

Kemper, Jongsook Kim .

MOLECULES AND CELLS, 2013, 36 (05) :385-392

[10] microRNAs in Diabetic Kidney Disease [J].

Chung, Arthur C. K. .

MICRORNA: MEDICAL EVIDENCE: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE, 2015, 888 :253-269

← 1 2 3 4 5 6 7 8 9 10 →