Ruthenium Catalyzed Directing Group-Free C2-Selective Carbenoid Functionalization of Indoles by α-Aryldiazoesters

被引：113

作者：

Chan, Wai-Wing

Yeung, Shing-Hin

Zhou, Zhongyuan

Chan, Albert S. C.

Yu, Wing-Yiu ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Inst Mol Technol Drug Discovery & Synth, Kowloon, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 03期

关键词：

C-H BOND; FRIEDEL-CRAFTS ALKYLATIONS; INTRAMOLECULAR CYCLOPROPANATION; ARYLATION; INSERTION; DECOMPOSITION; HETEROCYCLES; DIAZOESTERS; ACTIVATION; COMPLEXES;

D O I：

10.1021/ol9028226

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A directing group-free approach for C2-selective carbenoid functionalization of NH-indoles is presented. Using [RuCl2(p-cymene)](2) as catalyst and alpha-aryldiazoesters as carbenoid source, 2-alkylated indoles were obtained in up to 96% isolated yield. Similarly, a regioselective carbenoid functionalization of NH-pyrroles was also achieved.

引用

页码：604 / 607

页数：4

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