18F-FDG PET for Semiquantitative Evaluation of Acute Allograft Rejection and Immunosuppressive Therapy Efficacy in Rat Models of Liver Transplantation

被引：16

作者：

Tsuji, Atsushi B. ^{[2
]}

Morita, Miwa ^{[3
]}

Li, Xiao-Kang ^{[1
]}

Sogawa, Chizuru ^{[2
]}

Sudo, Hitomi ^{[2
]}

Sugyo, Aya ^{[2
]}

Fujino, Masayuki ^{[1
,4
]}

Sugioka, Atsushi ^{[3
]}

Koizumi, Mitsuru ^{[2
]}

Saga, Tsuneo ^{[2
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Lab Transplantat Immunol, Setagaya Ku, Tokyo 1578535, Japan

[2] Natl Inst Radiol Sci, Mol Imaging Ctr, Diagnost Imaging Grp, Chiba 260, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Surg, Aichi, Japan

[4] Natl Inst Hlth, AIDS Res Ctr, Tokyo 141, Japan

来源：

JOURNAL OF NUCLEAR MEDICINE | 2009年 / 50卷 / 05期

关键词：

acute rejection; F-18-FDG PET; immunosuppression; liver transplantation; SURVIVAL;

D O I：

10.2967/jnumed.108.058925

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with F-18-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of F-18-FDG accumulation in liver allografts was observed by PET on day 2. The F-18-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic F-18-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: F-18-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.

引用

页码：827 / 830

页数：4

共 10 条

[1] Belle S H, 1997, Liver Transpl Surg, V3, P93, DOI 10.1002/lt.500030201
[2] A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting
Hara, Yoshiaki
Funeshima-Fuji, Naoko
Fujino, Masayuki
Tokunaka, Kazuhiro
Abe, Fuminori
Sato, Yoshinobu
Hatakeyama, Katsuyoshi
Takahara, Shiro
Ezaki, Taichi
Kimura, Hiromistu
Li, Xiao-Kang
[J]. TRANSPLANTATION, 2007, 84 (03) : 407 - 414
[3] Use of 2-[18F]fluoro-2-deoxyglucose as a potential agent in the prediction of graft rejection by positron emission tomography
Heelan, BT
Osman, S
Blyth, A
Schnorr, L
Jones, T
George, AJT
[J]. TRANSPLANTATION, 1998, 66 (08) : 1101 - 1103
[4] KICG values a reliable real-time estimator of graft function, accurately predicts outcomes in adult living-donor liver transplantation
Hori, T
Iida, T
Yagi, S
Taniguchi, K
Yamamoto, C
Mizuno, S
Yamagiwa, K
Isaji, S
Uemoto, S
[J]. LIVER TRANSPLANTATION, 2006, 12 (04) : 605 - 613
[5] Ishimori T, 2002, J NUCL MED, V43, P658
[6] Jones KD, 1998, SEMIN DIAGN PATHOL, V15, P306
[7] REVERSAL OF TRANSPLANTATION IMMUNITY BY LIVER GRAFTING
KAMADA, N
DAVIS, HFS
ROSER, B
[J]. NATURE, 1981, 292 (5826) : 840 - 842
[8] Portmann B, 1995, Verh Dtsch Ges Pathol, V79, P277
[9] The immunological monitoring of alloreactive responses in liver transplant recipients:: A review
Reding, R
Gras, J
Truong, DQ
Wieërs, G
Latinne, D
[J]. LIVER TRANSPLANTATION, 2006, 12 (03) : 373 - 383
[10] Survival after liver transplantation in the United States: A disease-specific analysis of the UNOS database
Roberts, MS
Angus, DC
Bryce, CL
Valenta, Z
Weissfeld, L
[J]. LIVER TRANSPLANTATION, 2004, 10 (07) : 886 - 897

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