Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

被引：25

作者：

Zhu, Yuanyuan ^{[1
]}

Li, Boyu ^{[1
]}

Wang, Cui ^{[1
]}

Dong, Zhenghao ^{[1
]}

Zhong, Xiaoling ^{[1
]}

Wang, Kairong ^{[1
]}

Yan, Wenjin ^{[1
]}

Wang, Rui ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 21期

基金：

中国国家自然科学基金;

关键词：

DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; BETA; BETA-DISUBSTITUTED ENONES; AZOMETHINE YLIDES; GALIPEA-OFFICINALIS; TRIFLUOROMETHYLATED PYRROLIDINES; MICHAEL/MICHAEL ADDITION; STEREOGENIC CENTER; MICHAEL ADDITION;

D O I：

10.1039/c7ob01013c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An organocatalytic asymmetric method for the synthesis of 2-CF3 tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with beta-CF3 nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.

引用

页码：4544 / 4547

页数：4

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