Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

被引:38
|
作者
Khan, Abid
Silversides, Jon D.
Madden, Leigh
Greenman, John
Archibald, Stephen J.
机构
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England
[2] Univ Hull, Inst Clin Biosci, Kingston Upon Hull HU6 7RX, N Humberside, England
[3] Univ Hull, Med Res Lab, Kingston Upon Hull HU6 7RX, N Humberside, England
基金
英国惠康基金;
关键词
D O I
10.1039/b614557d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.
引用
收藏
页码:416 / 418
页数:3
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