Concomitant etoposide and cisplatin provided improved survival compared with docetaxel and cisplatin in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy
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作者:
Sen, Fatma
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Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Sen, Fatma
[1
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Tambas, Makbule
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Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Tambas, Makbule
[2
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Ozkaya, Kubra
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Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Ozkaya, Kubra
[2
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Guveli, Murat Emin
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Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Guveli, Murat Emin
[2
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Ciftci, Rumeysa
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Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Ciftci, Rumeysa
[1
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Ozkan, Berker
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机构:Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Ozkan, Berker
Oral, Ethem Nezih
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Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Oral, Ethem Nezih
[2
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Saglam, Esra Kaytan
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Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Saglam, Esra Kaytan
[2
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Saip, Pinar
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Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Saip, Pinar
[1
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Toker, Alper
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Istanbul Univ, Istanbul Fac Med, Dept Thorac Surg, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Toker, Alper
[3
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Demir, Adalet
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Istanbul Univ, Istanbul Fac Med, Dept Thorac Surg, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Demir, Adalet
[3
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Firat, Pinar
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Istanbul Univ, Istanbul Fac Med, Dept Pathol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Firat, Pinar
[4
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Aydiner, Adnan
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Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Aydiner, Adnan
[1
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Eralp, Yesim
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Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, TurkeyIstanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
Eralp, Yesim
[1
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机构:
[1] Istanbul Univ, Istanbul Fac Med, Inst Oncol, Dept Med Oncol, Istanbul, Turkey
[2] Istanbul Univ, Istanbul Fac Med, Dept Radiat Oncol, Istanbul, Turkey
[3] Istanbul Univ, Istanbul Fac Med, Dept Thorac Surg, Istanbul, Turkey
[4] Istanbul Univ, Istanbul Fac Med, Dept Pathol, Istanbul, Turkey
Presently, there is no consensus regarding which chemotherapy regimen is best to administer with radiotherapy in patients with locally advanced non-small-cell lung cancer (LA-NSCLC). Herein, our aim was to compare the outcome of patients treated with either etoposide-cisplatin (EP) or docetaxel-cisplatin (DP) in this curative setting. Patients treated with either EP or DP and concurrent radiotherapy from 2004 to2012 were identified and their detailed medical records and follow-up information were obtained for analysis in this retrospective study. Survival rates were compared using Cox proportional hazards regression models with adjustments for confounding parameters provided by propensity score methods. A total of 105 patients were treated with concurrent chemoradiotherapy for LA-NSCLC (stage IIB-IIIA-IIIB). The median ages were 54 years (range, 32-70 years) and 55 years (range, 37-73 years) in the EP (n= 50) and DP (n= 55) groups, respectively. The median follow-up time was 27 months (range, 1-132 months) in the EP group and 19 months (range, 1-96 months) in DP group. There was no significant difference in baseline clinicopathologic features including age, sex, performance status, histologic subtype, and clinical TNM stages between groups. In the univariate analysis, the median overall survival of patients treated with EP was higher than that of patients treated with DP (41 vs. 20 months, P= 0.003). Multivariate analysis further revealed a survival advantage with EP compared with DP (hazard ratio [HR], 0.46; 95% confidence interval: 0.25-0.83; P= 0.009). The toxicity profile of the 2treatment groups was similar except that pulmonary toxicity was higher in the DP group (grade 3-4: 0% vs. 6%, P= 0.024). Concurrent chemoradiotherapy with EP may provide more favorable outcomes than DP and with an acceptable safety profile.
机构:
Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Kusumoto, Sojiro
Hirose, Takashi
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Hirose, Takashi
Fukayama, Motoko
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Showa Univ, Sch Med, Div Thorac Surg, Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Fukayama, Motoko
Kataoka, Daisuke
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Showa Univ, Sch Med, Div Thorac Surg, Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Kataoka, Daisuke
Hamada, Kenji
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机构:
Showa Univ, Sch Med, Dept Radiol, Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Hamada, Kenji
Sugiyama, Tomohide
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Sugiyama, Tomohide
Shirai, Takao
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Shirai, Takao
Yamaoka, Toshimitsu
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Yamaoka, Toshimitsu
Okuda, Kentaro
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Okuda, Kentaro
Ohnishi, Tsukasa
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Ohnishi, Tsukasa
Ohmori, Tohru
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Showa Univ, Sch Med, Inst Mol Oncol, Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Ohmori, Tohru
Kadokura, Mitsutaka
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Showa Univ, Sch Med, Div Thorac Surg, Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
Kadokura, Mitsutaka
Adachi, Mitsuru
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Showa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, JapanShowa Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med,Shinagawa Ku, Tokyo 1428666, Japan
机构:
Hosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Univ Autonoma Madrid, Med Oncol Serv, Hosp La Paz, Madrid 28046, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Feliu, Jaime
Firvida, Jose Luis
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Med Oncol Serv, Orense 32005, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Firvida, Jose Luis
Castro, Javier
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Univ Autonoma Madrid, Med Oncol Serv, Hosp La Paz, Madrid 28046, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Castro, Javier
Madronal, Catherina
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机构:
Clin Corachan, Med Oncol Serv, Barcelona 08017, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Madronal, Catherina
Rodriguez-Jaraiz, Angeles
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机构:
H San Pedro Alcantara, Med Oncol Serv, Caceres 10003, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Rodriguez-Jaraiz, Angeles
Salgado, Mercedes
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Med Oncol Serv, Orense 32005, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Salgado, Mercedes
Belda-Iniesta, Cristobal
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Univ Autonoma Madrid, Med Oncol Serv, Hosp La Paz, Madrid 28046, Spain
Div Med Oncol, Madrid 28033, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Belda-Iniesta, Cristobal
Casado, Enrique
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Univ Autonoma Madrid, Med Oncol Serv, Hosp La Paz, Madrid 28046, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Casado, Enrique
Garcia-Mata, Jesus
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Med Oncol Serv, Orense 32005, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain
Garcia-Mata, Jesus
Gonzalez-Baron, Manuel
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Univ Autonoma Madrid, Med Oncol Serv, Hosp La Paz, Madrid 28046, Spain
Div Med Oncol, Madrid 28033, SpainHosp La Paz, Med Oncol Serv, Madrid 28046, Spain