Unraveling the role of connective tissue growth factor in diabetic nephropathy

被引:12
作者
Schmidt-Ott, K. M. [1 ]
机构
[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
关键词
D O I
10.1038/sj.ki.5002661
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Marked upregulation of the secreted extracellular matrix-associated protein connective tissue growth factor (CTGF) in the glomerulus coincides with the onset of diabetic nephropathy. Recent studies, including the one by Yokoi et al., shed light on the role of CTGF in glomerular injury.
引用
收藏
页码:375 / 376
页数:2
相关论文
共 13 条
[1]   Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β [J].
Abreu, JG ;
Ketpura, NI ;
Reversade, B ;
De Robertis, EM .
NATURE CELL BIOLOGY, 2002, 4 (08) :599-604
[2]   Diabetic nephropathy: Where hemodynamics meets metabolism [J].
Forbes, J. M. ;
Fukami, K. ;
Cooper, M. E. .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2007, 115 (02) :69-84
[3]   Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose [J].
Furlong, Fiona ;
Crean, John ;
Thornton, Laura ;
O'Leary, Ronan ;
Murphy, Madeline ;
Martin, Finian .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2007, 292 (06) :F1691-F1700
[4]   Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes [J].
Guha, Mausumee ;
Xu, Zhong-Gao ;
Tung, David ;
Lanting, Linda ;
Natarajan, Rama .
FASEB JOURNAL, 2007, 21 (12) :3355-3368
[5]   The CCN family of angiogenic regulators: The integrin connection [J].
Lau, LF ;
Lam, SCT .
EXPERIMENTAL CELL RESEARCH, 1999, 248 (01) :44-57
[6]   Wnt/β-catenin signaling modulates survival of high glucose-stressed mesangial cells [J].
Lin, Chun-Liang ;
Wang, Jeng-Yi ;
Huang, Yu-Ting ;
Kuo, Yu-Hsia ;
Surendran, Kameswaran ;
Wang, Feng-Sheng .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (10) :2812-2820
[7]   Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex [J].
Mercurio, S ;
Latinkic, B ;
Itasaki, N ;
Krumlauf, R ;
Smith, JC .
DEVELOPMENT, 2004, 131 (09) :2137-2147
[8]   Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells [J].
Murphy, M ;
Godson, C ;
Cannon, S ;
Kato, S ;
Mackenzie, HS ;
Martin, F ;
Brady, HR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (09) :5830-5834
[9]   BMP7 signaling in renal development and disease [J].
Patel, SR ;
Dressler, GR .
TRENDS IN MOLECULAR MEDICINE, 2005, 11 (11) :512-518
[10]   Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA [J].
Wahab, NA ;
Weston, BS ;
Mason, RM .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (02) :340-351