Scratching the surface: a role of pain-sensing TRPA1 in itch

被引：26

作者：

Xiao, Bailong ^{[1
]}

Patapoutian, Ardem ^{[2
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 05期

关键词：

COLD; MECHANISMS; CHANNELS;

D O I：

10.1038/nn.2813

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The molecular mechanisms of itch, particularly histamine-independent itch, are unclear. Wilson et al. report that TRPA1, an ion channel critical for pain sensation, also functions as an essential component of itch transduction.

引用

页码：540 / 542

页数：4

共 13 条

[1] Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin [J].

Bandell, M ;

Story, GM ;

Hwang, SW ;

Viswanath, V ;

Eid, SR ;

Petrus, MJ ;

Earley, TJ ;

Patapoutian, A .

NEURON, 2004, 41 (06) :849-857

[2] Cellular and Molecular Mechanisms of Pain [J].

Basbaum, Allan I. ;

Bautista, Diana M. ;

Scherrer, Gregory ;

Julius, David .

CELL, 2009, 139 (02) :267-284

[3] TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents [J].

Bautista, DM ;

Jordt, SE ;

Nikai, T ;

Tsuruda, PR ;

Read, AJ ;

Poblete, J ;

Yamoah, EN ;

Basbaum, AI ;

Julius, D .

CELL, 2006, 124 (06) :1269-1282

[4] TRPA1 Contributes to Cold Hypersensitivity [J].

del Camino, Donato ;

Murphy, Sarah ;

Heiry, Melissa ;

Barrett, Lee B. ;

Earley, Taryn J. ;

Cook, Colby A. ;

Petrus, Matt J. ;

Zhao, Michael ;

D'Amours, Marc ;

Deering, Nate ;

Brenner, Gary J. ;

Costigan, Michael ;

Hayward, Neil J. ;

Chong, Jayhong A. ;

Fanger, Christopher M. ;

Woolf, Clifford J. ;

Patapoutian, Ardem ;

Moran, Magdalene M. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (45) :15165-15174

[5] TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms [J].

Imamachi, Noritaka ;

Park, Goon Ho ;

Lee, Hyosang ;

Anderson, David J. ;

Simon, Melvin I. ;

Basbaum, Allan I. ;

Han, Sang-Kyou .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (27) :11330-11335

[6] TRPA1 acts as a cold sensor in vitro and in vivo [J].

Karashima, Yuji ;

Talavera, Karel ;

Everaerts, Wouter ;

Janssens, Annelies ;

Kwan, Kelvin Y. ;

Vennekens, Rudi ;

Nilius, Bernd ;

Voets, Thomas .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (04) :1273-1278

[7] An ion channel essential for sensing chemical damage [J].

Macpherson, Lindsey J. ;

Xiao, Bailong ;

Kwan, Kelvin Y. ;

Petrus, Matt J. ;

Dubin, Adrienne E. ;

Hwang, SunWook ;

Cravatt, Benjamin ;

Corey, David P. ;

Patapoutian, Ardem .

JOURNAL OF NEUROSCIENCE, 2007, 27 (42) :11412-11415

[8] Transient receptor potential channels: targeting pain at the source [J].

Patapoutian, Ardem ;

Tate, Simon ;

Woolf, Clifford J. .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (01) :55-68

[9] An Itch To Be Scratched [J].

Patel, Kush N. ;

Dong, Xinzhong .

NEURON, 2010, 68 (03) :334-339

[10] ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures [J].

Story, GM ;

Peier, AM ;

Reeve, AJ ;

Eid, SR ;

Mosbacher, J ;

Hricik, TR ;

Earley, TJ ;

Hergarden, AC ;

Andersson, DA ;

Hwang, SW ;

McIntyre, P ;

Jegla, T ;

Bevan, S ;

Patapoutian, A .

CELL, 2003, 112 (06) :819-829

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