A two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance biosensor

被引：33

作者：

Liu, Le ^{[3
]}

Ma, Suihua ^{[3
]}

Ji, Yanhong ^{[1
,2
]}

Chong, Xinyuan ^{[3
]}

Liu, Zhiyi ^{[3
]}

He, Yonghong ^{[3
]}

Guo, Jihua ^{[3
]}

机构：

[1] S China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[2] S China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[3] Tsinghua Univ, Lab Opt Imaging & Sensing, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China

来源：

REVIEW OF SCIENTIFIC INSTRUMENTS | 2011年 / 82卷 / 02期

基金：

美国国家科学基金会;

关键词：

SENSORS; WAVELENGTH;

D O I：

10.1063/1.3553028

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

We describe a two-dimensional polarization interferometry based parallel scan angular surface plasmon resonance (SPR) biosensing technique. The method of line-shaped light illumination and parallel scan offers a high throughput. The simultaneous record of SPR angular spectrum enables the system to be unaffected by the time-dependent variation of the light source. The polarization interferometry technique lowers the minimum of the SPR dip and thereby reduces the noise related to the light intensity. Refractive index resolutions of 1.4 x 10(-6) refractive index unit (RIU) under normal condition and 4.6 x 10(-7) RIU under a more time-consuming condition are achieved in our angle interrogation based sensor. Meanwhile, a manually prepared DNA microarray has been detected, showing the potential applications of this technique in microarray analysis. (C) 2011 American Institute of Physics. [doi:10.1063/1.3553028]

引用

页数：8

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