Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

被引：11

作者：

Manion, Maura ^{[1
]}

Dimitrova, Dimana ^{[2
]}

Pei, Luxin ^{[1
]}

Gea-Banacloche, Juan ^{[3
]}

Zelazny, Adrian ^{[4
]}

Lisco, Andrea ^{[1
]}

Zerbe, Christa ^{[1
]}

Freeman, Alexandra F. ^{[1
]}

Holland, Steven M. ^{[1
]}

Kanakry, Christopher G. ^{[2
]}

Kanakry, Jennifer A. ^{[2
]}

Sereti, Irini ^{[1
]}

机构：

[1] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NCI, NIH, Bethesda, MD 20892 USA

[3] Mayo Clin, Phoenix, AZ USA

[4] NIH, Dept Lab Med, Bldg 10, Bethesda, MD 20892 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 70卷 / 04期

基金：

美国国家卫生研究院;

关键词：

immune reconstitution; bone marrow transplantation; primary immunodeficiency; Mycobacterium avium; STEM-CELL TRANSPLANTATION; SYNDROME IRIS; INFECTION;

D O I：

10.1093/cid/ciz507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

引用

页码：676 / 679

页数：4

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