Dinuclear silver(I)-N-heterocyclic carbene complexes: Synthesis, characterization and larvicidal activity of bis-imidazolium dinuclear silver (I)-N-heterocyclic carbene complexes

被引：12

作者：

Selvarajoo, Puvana D. ^{[1
]}

Haque, Rosenani A. ^{[1
]}

Haziz, Umie F. M. ^{[1
]}

Avicor, Silas W. ^{[2
,3
]}

Wajidi, Mustafa F. F. ^{[2
]}

Razali, Mohd R. ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, George Town, Malaysia

[2] Univ Sains Malaysia, Mol Entomol Res Grp, Sch Distance Educ, George Town, Malaysia

[3] Cocoa Res Inst, Entomol Div, New Tafo Akim, Ghana

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2017年 / 175卷

关键词：

Imidazole; Ag(I)-NHC complex; X-ray diffraction; Larvicidal; Ae; aegypti; Culex quinquefasciatus; IN-VITRO ANTIBACTERIAL; CRYSTAL-STRUCTURES; SUBSTITUTED IMIDAZOL-2-YLIDENES; BENZIMIDAZOLIUM SALTS; ANTICANCER; LIGANDS; AG(I);

D O I：

10.1016/j.jinorgbio.2017.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New synthesized bis-imidazolium salts that are linked by xylyl derivatives moiety, 1-4 was reacted with Ag2O to facilitate the formation of dinuclear Ag(I)-N-heterocyclic carbene (NHC) complexes, 5-8, respectively. All the synthesized ligand salts and complexes were characterized by H-1 and C-13 NMR, FTIR spectroscopy and elemental analysis. Molecular structures of compounds 3, 5, and 7 were elucidated by single crystal X-ray diffraction analyses. Larvicidal studies against the Aedes aegypti and Culex quinquefasciatus were carried out on all synthesized compounds following the World Health Organization standard larval susceptibility test. All the imidazolium salts were found inactive while the activity of the dinuclear Ag(I)-NHC complexes on mosquito larvae are varies with the nature of the ligands. Complex 7 has high activity on Ae. aegypti and Cx. quinquefasciatus, emphasising its potential as a larvicidal compound.

引用

页码：232 / 238

页数：7

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