Positive selection of T cells, an in vitro view

被引：20
作者：
Dervovic, Dzenetdina
Zuniga-Pfluecker, Juan Carlos [1 ]
机构：
[1] Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
来源：
SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 05期
基金：
加拿大健康研究院;
关键词：
T cell development; Thymic stromal cells; MHC; TCR; Positive selection; FTOC; In vitro culture; OP9-DL1; CD4/CD8 LINEAGE COMMITMENT; NEGATIVE SELECTION; FETAL THYMUS; THYMOCYTE DEVELOPMENT; RUNX PROTEINS; CD4; LINEAGE; CD4(+)CD8(+) THYMOCYTES; CD4(+)8(+) THYMOCYTES; CORECEPTOR EXPRESSION; CD4+CD8+ THYMOCYTES;
D O I：
10.1016/j.smim.2010.04.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The thymus provides a unique set of cues for the effective selection and differentiation of CD4 and CD8 T-cells from a pool of immature thymocytes. Several approaches have been used to elucidate the complex set of intrathymic interactions that mediate these selection and differentiation events. Over the years, a number of different in vitro approaches have been developed and employed to assist in the identification of the cellular and molecular players that underpin thymic function. Here we provide an overview of the advances, which were obtained by in vitro approaches, to our understanding of the process of positive selection and CD4/CD8 lineage commitment. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：276 / 286
页数：11
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